UniProt P02714
Acetylcholine receptor subunit gamma (P02714)
Acetylcholine receptor subunit gamma (UniProt P02714): 25 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 154 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02714
- Protein
- Acetylcholine receptor subunit gamma
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 154 · 16 records with a druggable one
Structures
26 records of P02714 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UWZ | Cryo-EM structure of Torpedo acetylcholine receptor in complex with alpha-bungarotoxin | electron microscopy | E | NAG, MAN, POV | 10 (best 0.76) |
| 6UWZ | Cryo-EM structure of torpedo acetylcholine receptor in complex with alpha-bungarotoxin | electron microscopy | E | NAG, MAN, POV | — |
| 7QKO | Torpedo muscle-type nicotinic acetylcholine receptor - Resting conformation | electron microscopy | E | NAG, MAN, POV | 10 (best 0.80) |
| 7QKO | Torpedo muscle-type nicotinic acetylcholine receptor - resting conformation | electron microscopy | E | NAG, MAN, POV | — |
| 7QL5 | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | electron microscopy | E | MAN, NAG, NCT, POV | 10 (best 0.85) |
| 7QL5 | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | electron microscopy | E | NAG, MAN, NCT, POV | — |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | E | NAG, BMA, MAN, CCE | 10 (best 0.83) |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | E | NAG, MAN, CCE | — |
| 7SMM | Cryo-EM structure of Torpedo acetylcholine receptor in apo form | electron microscopy | E | NAG, MAN, POV | 9 (best 0.80) |
| 7SMM | Cryo-EM structure of torpedo acetylcholine receptor in apo form | electron microscopy | E | NAG, MAN, POV | — |
| 7SMQ | Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | E | NAG, MAN, POV, CLR | 9 (best 0.79) |
| 7SMQ | Cryo-EM structure of torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | E | NAG, MAN, POV, CLR | — |
| 7SMR | Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | E | NAG, MAN, POV, CCE | 8 (best 0.84) |
| 7SMR | Cryo-EM structure of torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | E | NAG, MAN, POV, CCE | — |
| 7SMS | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine | electron microscopy | E | NAG, MAN, TC9, POV | 10 (best 0.83) |
| 7SMS | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine | electron microscopy | E | NAG, MAN, TC9, POV | — |
| 7SMT | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine and carbachol | electron microscopy | E | NAG, MAN, POV, TC9 | 8 (best 0.83) |
| 7SMT | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine and carbachol | electron microscopy | E | NAG, MAN, POV, TC9 | — |
| 7Z14 | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | E | NAG, MAN | 11 (best 0.72) |
| 7Z14 | Cryo-EM structure of torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | E | NAG, MAN | 11 (best 0.72) |
| 8ESK | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | E | NAG, MAN, RBR, POV | 10 (best 0.81) |
| 8F2S | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | E | NAG, MAN, RBR, POV | 10 (best 0.86) |
| 8F6Y | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate… | electron microscopy | E | NAG, MAN, CHT, POV | 10 (best 0.82) |
| 8F6Z | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine… | electron microscopy | E | NAG, MAN, SCK, POV | 10 (best 0.84) |
| 8QQM | nicotinic acetylcholine receptor in intact synaptic membrane | electron microscopy | E | — | 8 (best 0.87) |
| P02714 | AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit gamma (P02714) | predicted | A | — | — |
Ligands
- MAN · alpha-D-mannopyranose · in 24 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 24 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 20 records
- CCE · 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium · in 4 records
- TC9 · D-tubocurarine · in 4 records
- CLR · Cholesterol · in 2 records
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 2 records
- RBR · rocuronium · in 2 records
- BMA · beta-D-mannopyranose · in 1 record
- CHT · Choline ion · in 1 record
- SCK · 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(n,n,n-trimethylethanaminium) · in 1 record
Experiment against prediction
- 7Z14 chain E against the predicted model P02714: TM-score 0.99, RMSD 0.58 Å
- 7Z14 chain E against the predicted model P02714: TM-score 0.99, RMSD 0.58 Å
- 7QKO chain E against the predicted model P02714: TM-score 0.99, RMSD 0.64 Å
- 7QKO chain E against the predicted model P02714: TM-score 0.99, RMSD 0.64 Å
- 6UWZ chain E against the predicted model P02714: TM-score 0.99, RMSD 0.68 Å
- 6UWZ chain E against the predicted model P02714: TM-score 0.99, RMSD 0.68 Å
- 7SMM chain E against the predicted model P02714: TM-score 0.99, RMSD 0.70 Å
- 7SMM chain E against the predicted model P02714: TM-score 0.99, RMSD 0.70 Å
- 7SMQ chain E against the predicted model P02714: TM-score 0.99, RMSD 0.72 Å
- 7SMQ chain E against the predicted model P02714: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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