UniProt P02710
Acetylcholine receptor subunit alpha (P02710)
Acetylcholine receptor subunit alpha (UniProt P02710): 37 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 167 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02710
- Protein
- Acetylcholine receptor subunit alpha
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 167 · 10 records with a druggable one
Structures
38 records of P02710 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ABT | NMR solution structure of an alpha-BUNGAROTOXIN(SLASH)NICOTINIC receptor peptide complex | solution nmr | B | — | — |
| 1ABT | NMR solution structure of an alpha-BUNGAROTOXIN(SLASH)NICOTINIC receptor peptide complex | solution nmr | B | — | — |
| 1DXZ | M2 transmembrane segment of alpha-subunit of nicotinic acetylcholine receptor from torpedo… | solution nmr | A | — | — |
| 1DXZ | M2 transmembrane segment of alpha-subunit of nicotinic acetylcholine receptor from torpedo… | solution nmr | A | — | — |
| 1IDG | The NMR solution structure of the complex formed between alpha-bungarotoxin and an 18MER cognate… | solution nmr | B | — | — |
| 1IDG | The NMR solution structure of the complex formed between alpha- bungarotoxin and an 18MER cognate… | solution nmr | B | — | — |
| 1IDH | The NMR solution structure of the complex formed between alpha-bungarotoxin and an 18MER cognate… | solution nmr | B | — | — |
| 1IDH | The NMR solution structure of the complex formed between alpha- bungarotoxin and an 18MER cognate… | solution nmr | B | — | — |
| 1LXG | Solution structure of alpha-cobratoxin complexed with a cognate peptide (structure ensemble) | solution nmr | B | — | — |
| 1LXG | Solution structure of alpha-cobratoxin complexed with a cognate peptide (structure ensemble) | solution nmr | B | — | — |
| 1LXH | Solution structure of alpha-cobratoxin complexed with a cognate peptide (minimized average… | solution nmr | B | — | — |
| 1LXH | Solution structure of alpha-cobratoxin complexed with a cognate peptide (minimized average… | solution nmr | B | — | — |
| 1TOR | Molecular dynamics simulation from 2D-NMR data of the free achr mir decapeptide and the… | solution nmr | A | — | — |
| 1TOR | Molecular dynamics simulation from 2D-NMR data of the free achr mir decapeptide and the… | solution nmr | A | — | — |
| 1TOS | Torpedo californica achr receptor [ALA76] analogue complexed with the anti-acetylcholine MAB6… | solution nmr | A | — | — |
| 1TOS | Torpedo californica achr receptor [ALA76] analogue complexed with the anti-acetylcholine MAB6… | solution nmr | A | — | — |
| 3MRA | M3 transmembrane segment of alpha-subunit of nicotinic acetylcholine receptor from torpedo… | solution nmr | A | — | — |
| 3MRA | M3 transmembrane segment of alpha-subunit of nicotinic acetylcholine receptor from torpedo… | solution nmr | A | — | — |
| 6UWZ | Cryo-EM structure of torpedo acetylcholine receptor in complex with alpha-bungarotoxin | electron microscopy | A, D | NAG, BMA, MAN, POV | — |
| 7QKO | Torpedo muscle-type nicotinic acetylcholine receptor - resting conformation | electron microscopy | A, D | NAG, BMA, MAN, POV | — |
| 7QL5 | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | electron microscopy | A, D | NAG, BMA, MAN, NCT, POV | — |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | A, D | NAG, BMA, MAN, CCE | 17 (best 0.83) |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | A, D | NAG, BMA, MAN, CCE | — |
| 7SMM | Cryo-EM structure of torpedo acetylcholine receptor in apo form | electron microscopy | A, D | NAG, BMA, MAN, POV, CLR | — |
| 7SMQ | Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | A, D | NAG, BMA, MAN, POV, CLR | 15 (best 0.79) |
| 7SMQ | Cryo-EM structure of torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | A, D | NAG, BMA, MAN, POV, CLR | — |
| 7SMR | Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | A, D | NAG, BMA, MAN, CCE, CLR, POV | 17 (best 0.84) |
| 7SMR | Cryo-EM structure of torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | A, D | NAG, BMA, MAN, CCE, CLR, POV | — |
| 7SMS | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine | electron microscopy | A, D | NAG, BMA, MAN, CLR, TC9, POV | 17 (best 0.83) |
| 7SMS | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine | electron microscopy | A, D | NAG, BMA, MAN, CLR, TC9, POV | — |
| 7SMT | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine and carbachol | electron microscopy | A, D | NAG, BMA, MAN, CCE, CLR, POV | — |
| 7Z14 | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | A, D | NAG, BMA, MAN | 16 (best 0.72) |
| 7Z14 | Cryo-EM structure of torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | A, D | NAG, BMA, MAN | 16 (best 0.72) |
| 8ESK | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | A, D | NAG, BMA, MAN, RBR, POV, CLR | 16 (best 0.81) |
| 8F2S | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | A, D | NAG, BMA, MAN, RBR, POV, CLR | 18 (best 0.86) |
| 8F6Y | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate… | electron microscopy | A, D | NAG, BMA, MAN, V8D, CHT, CLR | 18 (best 0.82) |
| 8F6Z | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine… | electron microscopy | A, D | NAG, BMA, MAN, SCK, CLR, POV | 17 (best 0.84) |
| P02710 | AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit alpha (P02710) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 19 records
- MAN · alpha-D-mannopyranose · in 19 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 19 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 15 records
- CLR · Cholesterol · in 12 records
- CCE · 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium · in 5 records
- TC9 · D-tubocurarine · in 3 records
- RBR · rocuronium · in 2 records
- CHT · Choline ion · in 1 record
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 1 record
- SCK · 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(n,n,n-trimethylethanaminium) · in 1 record
- V8D · Ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate · in 1 record
Experiment against prediction
- 7Z14 chain D against the predicted model P02710: TM-score 0.98, RMSD 0.89 Å
- 7Z14 chain D against the predicted model P02710: TM-score 0.98, RMSD 0.89 Å
- 7Z14 chain A against the predicted model P02710: TM-score 0.98, RMSD 0.98 Å
- 7Z14 chain A against the predicted model P02710: TM-score 0.98, RMSD 0.98 Å
- 7QL5 chain A against the predicted model P02710: TM-score 0.98, RMSD 1.07 Å
- 7QKO chain D against the predicted model P02710: TM-score 0.98, RMSD 1.05 Å
- 7QL6 chain A against the predicted model P02710: TM-score 0.98, RMSD 1.09 Å
- 7QL6 chain A against the predicted model P02710: TM-score 0.98, RMSD 1.09 Å
- 7SMM chain D against the predicted model P02710: TM-score 0.98, RMSD 1.15 Å
- 7SMQ chain D against the predicted model P02710: TM-score 0.98, RMSD 1.15 Å
Elsewhere
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