UniProt P02647
Apolipoprotein A-I (P02647)
Apolipoprotein A-I (UniProt P02647): 50 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02647
- Protein
- Apolipoprotein A-I
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 26 · 3 records with a druggable one
Structures
51 records of P02647 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AV1 | Crystal structure of human apolipoprotein a-I | x-ray diffraction | A, B, C, D | — | 12 (best 0.84) |
| 1AV1 | Crystal structure of human apolipoprotein a-I | x-ray diffraction | A, B, C, D | — | — |
| 1GW3 | The helix-hinge-helix structural motif in human apolipoprotein a-I determined by NMR spectroscopy… | solution nmr | A | — | — |
| 1GW3 | The helix-hinge-helix structural motif in human apolipoprotein a-I determined by NMR spectroscopy… | solution nmr | A | — | — |
| 1GW4 | The helix-hinge-helix structural motif in human apolipoprotein a-I determined by NMR spectroscopy… | solution nmr | A | — | — |
| 1GW4 | The helix-hinge-helix structural motif in human apolipoprotein a-I determined by NMR spectroscopy… | solution nmr | A | — | — |
| 1ODP | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 6.6, 37 degrees celsius and… | solution nmr | A | — | — |
| 1ODP | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 6.6, 37 degrees celsius and… | solution nmr | A | — | — |
| 1ODQ | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 3.7, 37 degrees celsius and… | solution nmr | A | — | — |
| 1ODQ | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 3.7, 37 degrees celsius and… | solution nmr | A | — | — |
| 1ODR | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 6.0, 37 degrees celsius and… | solution nmr | A | — | — |
| 1ODR | Peptide of human apoa-I residues 166-185. NMR, 5 structures at pH 6.0, 37 degrees celsius and… | solution nmr | A | — | — |
| 2MSC | NMR data-driven model of GTPase KRas-GDP tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2MSC | NMR data-driven model of GTPase KRAS-GDP tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2MSD | NMR data-driven model of GTPase KRas-GNP tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2MSD | NMR data-driven model of GTPase KRAS-gnp tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2MSE | NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2MSE | NMR data-driven model of GTPase KRAS-GNP:ARAFRBD complex tethered to a lipid-bilayer nanodisc | solution nmr | A, C | — | — |
| 2N5E | The 3D solution structure of discoidal high-density lipoprotein particles | solution nmr | A, B | — | — |
| 2N5E | The 3D solution structure of discoidal high-density lipoprotein particles | solution nmr | A, B | — | — |
| 3K2S | Solution structure of double super helix model | solution scattering | A, B | — | — |
| 3K2S | Solution structure of double super helix model | solution scattering | A, B | — | — |
| 3R2P | 2.2 Angstrom Crystal Structure of C Terminal Truncated Human Apolipoprotein A-I Reveals the… | x-ray diffraction | A | — | — |
| 3R2P | 2.2 ångström crystal structure of C terminal truncated human apolipoprotein a-I reveals the… | x-ray diffraction | A | — | — |
| 4V6M | Structure of the ribosome-SecYE complex in the membrane environment | electron microscopy | A0, A1 | — | — |
| 6CC9 | NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | solution nmr | A, C | PCW, 17F | 2 (best 0.40) |
| 6CC9 | NMR data-driven model of GTPase KRAS-GMPPNP:CMPD2 complex tethered to a nanodisc | solution nmr | A, C | PCW, 17F | — |
| 6CCH | NMR data-driven model of GTPase KRas-GMPPNP tethered to a nanodisc (E3 state) | solution nmr | A, C | PCW, 17F | — |
| 6CCH | NMR data-driven model of GTPase KRAS-gmppnp tethered to a nanodisc (E3 state) | solution nmr | A, C | PCW, 17F | — |
| 6CCX | NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | solution nmr | A, C | PCW, 17F | — |
| 6CCX | NMR data-driven model of GTPase KRAS-GMPPNP:CMPD2 complex tethered to a nanodisc | solution nmr | A, C | PCW, 17F | — |
| 6CLZ | MT1-MMP HPX domain with Blade 4 Loop Bound to Nanodiscs | solution nmr | B, C | PX4 | 5 (best 0.52) |
| 6CLZ | MT1-mmp hpx domain with blade 4 loop bound to nanodiscs | solution nmr | B, C | PX4 | — |
| 6CM1 | MT1-MMP HPX Domain with Blade 2 Loop Bound to Nanodiscs | solution nmr | B, C | PX4 | 5 (best 0.43) |
| 6CM1 | MT1-mmp hpx domain with blade 2 loop bound to nanodiscs | solution nmr | B, C | PX4 | — |
| 6PTS | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A) | solution nmr | A, C | PCW, 17F | — |
| 6PTS | NMR data-driven model of KRAS-GMPPNP:RBD-crd complex tethered to a nanodisc (state a) | solution nmr | A, C | PCW, 17F | — |
| 6PTW | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B) | solution nmr | A, C | PCW, 17F | — |
| 6PTW | NMR data-driven model of KRAS-GMPPNP:RBD-crd complex tethered to a nanodisc (state B) | solution nmr | A, C | PCW, 17F | — |
| 6W4E | NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc | solution nmr | A, D | PCW, 17F | 1 (best 0.28) |
| 6W4E | NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc | solution nmr | A, D | PCW, 17F | — |
| 6W4F | NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc | solution nmr | A, D | PCW, 17F | — |
| 6W4F | NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc | solution nmr | A, D | PCW, 17F | — |
| 7KJR | Cryo-EM structure of SARS-CoV-2 ORF3a | electron microscopy | C, D | PEE | — |
| 7KJR | Cryo-EM structure of SARS-cov-2 ORF3A | electron microscopy | C, D | PEE | — |
| 7RSC | NMR-driven structure of the KRAS4B-G12D alpha-alpha" dimer on a lipid bilayer nanodisc" | solution nmr | D, E | 7Q9, 17F | — |
| 7RSC | NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc | solution nmr | D, E | 7Q9, 17F | — |
| 7RSE | NMR-driven structure of the KRAS4B-G12D alpha-beta" dimer on a lipid bilayer nanodisc" | solution nmr | D, E | 7Q9, 17F | — |
| 7RSE | NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc | solution nmr | D, E | 7Q9, 17F | — |
| 8EQS | Structure of SARS-CoV-1 Orf3a in late endosome/lysosome-like environment, MSP1D1 nanodisc | electron microscopy | C, D | PEE | 1 (best 0.84) |
| P02647 | AlphaFold monomer V2.0 prediction for apolipoprotein a-I (P02647) | predicted | A | — | — |
Ligands
- 17F · O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine · in 18 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 14 records
- 7Q9 · [(2~{R})-3-[oxidanyl-[2-(trimethyl-$L^{4}-azanyl) ethoxy]phosphoryl]oxy-2-propanoyloxy-propyl] (~{Z})-octadec-9-enoate · in 4 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 4 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 3 records
Experiment against prediction
- 7KJR chain C against the predicted model P02647: TM-score 0.75, RMSD 0.85 Å
- 7KJR chain C against the predicted model P02647: TM-score 0.75, RMSD 0.85 Å
- 7KJR chain D against the predicted model P02647: TM-score 0.73, RMSD 0.92 Å
- 7KJR chain D against the predicted model P02647: TM-score 0.73, RMSD 0.92 Å
- 8EQS chain C against the predicted model P02647: TM-score 0.63, RMSD 1.18 Å
- 8EQS chain D against the predicted model P02647: TM-score 0.63, RMSD 1.18 Å
- 7RSE chain D against the predicted model P02647: TM-score 0.59, RMSD 4.09 Å
- 7RSE chain D against the predicted model P02647: TM-score 0.59, RMSD 4.09 Å
- 6PTW chain A against the predicted model P02647: TM-score 0.59, RMSD 4.65 Å
- 6PTW chain A against the predicted model P02647: TM-score 0.59, RMSD 4.65 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.