UniProt P00960

Glycine--tRNA ligase alpha subunit (P00960)

Glycine--tRNA ligase alpha subunit (UniProt P00960), EC 6.1.1.14: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P00960
Protein: Glycine--tRNA ligase alpha subunit
EC: 6.1.1.14
Experimental structures: 4
Predicted models: 1
Ligands: 4
Pockets: 24 · 3 records with a druggable one

Structures

5 records of P00960 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7EIV	heterotetrameric glycyl-tRNA synthetase from Escherichia coli	x-ray diffraction	A, B	MG, ANP, GLY	8 (best 0.80)
7EIV	Heterotetrameric glycyl-tRNA synthetase from escherichia COLI	x-ray diffraction	A, B	MG, ANP	—
7QCF	X-ray crystallographic structure of E. COLI K-12 glycyl-tRNA synthetase alpha subunit (glyq)	x-ray diffraction	A, B, C, D	—	—
7YSE	Crystal structure of E. coli heterotetrameric GlyRS in complex with tRNA	x-ray diffraction	A, B	JPO, MG	15 (best 0.87)
P00960	AlphaFold monomer V2.0 prediction for glycine--tRNA ligase alpha subunit (P00960)	predicted	A	—	1 (best 0.69)

Ligands

MG · Magnesium ion · in 3 records
ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
GLY · Glycine · in 1 record
JPO · [(2R,3S,4R,5R)-5-(6-azanyl-2-chloranyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl N-(2-azanylethanoyl)sulfamate · in 1 record

Experiment against prediction

7EIV chain A against the predicted model P00960: TM-score 0.98, RMSD 0.82 Å
7YSE chain A against the predicted model P00960: TM-score 0.98, RMSD 0.85 Å
7EIV chain B against the predicted model P00960: TM-score 0.98, RMSD 0.87 Å
7YSE chain B against the predicted model P00960: TM-score 0.98, RMSD 0.90 Å
7EIV chain A against the predicted model P00960: TM-score 0.98, RMSD 0.82 Å
7EIV chain B against the predicted model P00960: TM-score 0.98, RMSD 0.87 Å
7QCF chain C against the predicted model P00960: TM-score 0.90, RMSD 2.10 Å
7QCF chain B against the predicted model P00960: TM-score 0.89, RMSD 2.26 Å
7QCF chain A against the predicted model P00960: TM-score 0.89, RMSD 2.28 Å
7QCF chain D against the predicted model P00960: TM-score 0.89, RMSD 2.34 Å

Elsewhere

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