UniProt P00751
Complement factor B (P00751)
Complement factor B (UniProt P00751), EC 3.4.21.47: 40 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 114 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00751
- Protein
- Complement factor B
- EC
- 3.4.21.47
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 114 · 12 records with a druggable one
Structures
41 records of P00751 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DLE | Factor B serine protease domain | x-ray diffraction | A, B | — | — |
| 1DLE | Factor B serine protease domain | x-ray diffraction | A, B | — | — |
| 1Q0P | A domain of Factor B | x-ray diffraction | A | — | — |
| 1Q0P | A domain of factor B | x-ray diffraction | A | — | — |
| 1RRK | Crystal Structure Analysis of the Bb segment of Factor B | x-ray diffraction | A | — | — |
| 1RRK | Crystal structure analysis of the bb segment of factor B | x-ray diffraction | A | — | — |
| 1RS0 | Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP) | x-ray diffraction | A | — | — |
| 1RS0 | Crystal structure analysis of the bb segment of factor B complexed with di-isopropyl-phosphate (dip) | x-ray diffraction | A | — | — |
| 1RTK | Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid | x-ray diffraction | A | — | — |
| 1RTK | Crystal structure analysis of the bb segment of factor B complexed with 4-guanidinobenzoic acid | x-ray diffraction | A | — | — |
| 2OK5 | Human Complement factor B | x-ray diffraction | A | — | — |
| 2OK5 | Human complement factor B | x-ray diffraction | A | — | — |
| 2WIN | C3 convertase (C3bBb) stabilized by SCIN | x-ray diffraction | I, J, K, L | — | — |
| 2WIN | C3 convertase (C3BBB) stabilized by scin | x-ray diffraction | I, J, K, L | — | — |
| 2XWB | Crystal Structure of Complement C3b in complex with Factors B and D | x-ray diffraction | F, H | — | — |
| 2XWB | Crystal structure of complement C3B in complex with factors B and D | x-ray diffraction | F, H | — | — |
| 2XWJ | Crystal Structure of Complement C3b in Complex with Factor B | x-ray diffraction | I, J, K, L | — | — |
| 2XWJ | Crystal structure of complement C3B in complex with factor B | x-ray diffraction | I, J, K, L | — | — |
| 3HRZ | Cobra Venom Factor (CVF) in complex with human factor B | x-ray diffraction | D | — | — |
| 3HRZ | Cobra venom factor (cvf) in complex with human factor B | x-ray diffraction | D | — | — |
| 3HS0 | Cobra Venom Factor (CVF) in complex with human factor B | x-ray diffraction | D, I | — | — |
| 3HS0 | Cobra venom factor (cvf) in complex with human factor B | x-ray diffraction | D, I | — | — |
| 6QSW | Complement factor B protease domain in complex with the reversible inhibitor… | x-ray diffraction | AAA, BBB, CCC | SO4, JGT | 10 (best 0.77) |
| 6QSX | Complement factor B protease domain in complex with the reversible inhibitor… | x-ray diffraction | AAA, BBB | SO4, JGN, ZN | 6 (best 0.73) |
| 6RAV | Complement factor B protease domain in complex with the reversible inhibitor… | x-ray diffraction | AAA, BBB | SO4, JGQ, ZN | — |
| 6RUR | Structure of the SCIN stabilized C3bBb convertase bound to properdin | x-ray diffraction | J, L | NAG, MG | 5 (best 0.74) |
| 6RUR | Structure of the scin stabilized C3BBB convertase bound to properdin | x-ray diffraction | J, L | NAG, MG | — |
| 6RUV | Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory… | x-ray diffraction | J, L | NAG, MG | 3 (best 0.68) |
| 6RUV | Structure of the scin stabilized C3BBB convertase bound to properdin and a the non-inhibitory… | x-ray diffraction | J, L | NAG, MG | — |
| 6T8V | Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole | x-ray diffraction | AAA, BBB | SO4, MVK, ZN | 5 (best 0.75) |
| 6T8W | Complement factor B in complex with (-)-4-(1-((5,7-Dimethyl-1H-indol-4-yl)methyl)piperidin-2-yl)benz… | x-ray diffraction | AAA, BBB | SO4, MVW, ZN | 6 (best 0.74) |
| 7JTN | Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases | x-ray diffraction | A, C | — | 20 (best 0.80) |
| 7JTN | Human complement factor B inhibited by a slow off-rate modified aptamer of 29 bases | x-ray diffraction | A, C | — | — |
| 7JTQ | Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases | x-ray diffraction | A, C | — | 20 (best 0.85) |
| 7JTQ | Human complement factor B inhibited by a slow off-rate modified aptamer of 31 bases | x-ray diffraction | A, C | — | — |
| 7NOZ | Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP | x-ray diffraction | F | NAG, MG | 14 (best 0.85) |
| 7NOZ | Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3B:FB:FP | x-ray diffraction | F | NAG, MG | — |
| 8ENU | Structure of the C3bB proconvertase in complex with lufaxin | electron microscopy | D | NAG | 10 (best 0.85) |
| 8EOK | Structure of the C3bB proconvertase in complex with lufaxin and factor Xa | electron microscopy | D | MG, NAG | 9 (best 0.78) |
| 8UIN | Structure of the C3bBb-albicin complex | electron microscopy | J, X | — | 6 (best 0.70) |
| P00751 | AlphaFold monomer V2.0 prediction for complement factor B (P00751) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- MG · Magnesium ion · in 7 records
- SO4 · Sulfate ion · in 5 records
- ZN · Zinc ion · in 4 records
- JGN · [(2~{S},4~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]-4-methoxy-piperidin-2-yl]methanol · in 1 record
- JGQ · 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid · in 1 record
- JGT · ~{N}-(2-bromanyl-4-methyl-naphthalen-1-yl)-4,5-dihydro-1~{H}-imidazol-2-amine · in 1 record
- MVK · 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid · in 1 record
- MVW · 5,7-dimethyl-4-[[(2~{S})-2-phenylpiperidin-1-yl]methyl]-1~{H}-indole · in 1 record
Experiment against prediction
- 6QSW chain AAA against the predicted model P00751: TM-score 0.99, RMSD 0.80 Å
- 6QSW chain CCC against the predicted model P00751: TM-score 0.99, RMSD 0.84 Å
- 6QSW chain BBB against the predicted model P00751: TM-score 0.98, RMSD 1.12 Å
- 1DLE chain B against the predicted model P00751: TM-score 0.97, RMSD 1.13 Å
- 1DLE chain B against the predicted model P00751: TM-score 0.97, RMSD 1.13 Å
- 6T8V chain BBB against the predicted model P00751: TM-score 0.97, RMSD 1.40 Å
- 6RAV chain BBB against the predicted model P00751: TM-score 0.96, RMSD 1.47 Å
- 1DLE chain A against the predicted model P00751: TM-score 0.96, RMSD 1.36 Å
- 1DLE chain A against the predicted model P00751: TM-score 0.96, RMSD 1.36 Å
- 6T8W chain BBB against the predicted model P00751: TM-score 0.96, RMSD 1.50 Å
Elsewhere
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