UniProt P00736
Complement C1r subcomponent (P00736)
Complement C1r subcomponent (UniProt P00736), EC 3.4.21.41: 20 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P00736
- Protein
- Complement C1r subcomponent
- EC
- 3.4.21.41
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 40 · 3 records with a druggable one
Structures
21 records of P00736 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1APQ | Structure of the EGF-like module of human C1R, NMR, 19 structures | solution nmr | A | — | — |
| 1APQ | Structure of the EGF-like module of human C1R, NMR, 19 structures | solution nmr | A | — | — |
| 1GPZ | The crystal structure of the zymogen catalytic domain of complement protease C1R | x-ray diffraction | A, B | — | — |
| 1GPZ | The crystal structure of the zymogen catalytic domain of complement protease C1R | x-ray diffraction | A, B | — | — |
| 1MD7 | Monomeric structure of the zymogen of complement protease C1r | x-ray diffraction | A | — | — |
| 1MD7 | Monomeric structure of the zymogen of complement protease C1R | x-ray diffraction | A | — | — |
| 1MD8 | Monomeric structure of the active catalytic domain of complement protease C1r | x-ray diffraction | A | — | — |
| 1MD8 | Monomeric structure of the active catalytic domain of complement protease C1R | x-ray diffraction | A | — | — |
| 2QY0 | Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts | x-ray diffraction | A, B, C, D | — | — |
| 2QY0 | Active dimeric structure of the catalytic domain of C1R reveals enzyme-product like contacts | x-ray diffraction | A, B, C, D | — | — |
| 6F1C | C1rC1s complex | x-ray diffraction | A, C | NAG, CA, NA | 14 (best 0.71) |
| 6F1C | C1RC1S complex | x-ray diffraction | A, C | NAG, CA, NA | — |
| 6F1D | CUB2 domain of C1r | x-ray diffraction | A | CA, NA | — |
| 6F1D | CUB2 domain of C1R | x-ray diffraction | A | CA, NA | — |
| 6F1H | C1rC1s complex | x-ray diffraction | A, C | NAG, CA, NA, LYS | 16 (best 0.76) |
| 6F1H | C1RC1S complex | x-ray diffraction | A, C | NAG, CA, NA | — |
| 6F39 | C1r homodimer CUB1-EGF-CUB2 | x-ray diffraction | A, B | NAG, CA, NA | 10 (best 0.81) |
| 6F39 | C1R homodimer CUB1-EGF-CUB2 | x-ray diffraction | A, B | NAG, CA, NA | — |
| 7MZT | Borrelia burgdorferi BBK32-C in complex with an autolytic fragment of human C1r at 4.1A | x-ray diffraction | A, B | NAG | — |
| 7MZT | Borrelia burgdorferi BBK32-C in complex with an autolytic fragment of human C1R at 4.1A | x-ray diffraction | A, B | NAG | — |
| P00736 | AlphaFold monomer V2.0 prediction for complement C1R subcomponent (P00736) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6F1D chain A against the predicted model P00736: TM-score 0.98, RMSD 0.70 Å
- 6F1D chain A against the predicted model P00736: TM-score 0.98, RMSD 0.70 Å
- 2QY0 chain B against the predicted model P00736: TM-score 0.98, RMSD 0.89 Å
- 2QY0 chain B against the predicted model P00736: TM-score 0.98, RMSD 0.89 Å
- 2QY0 chain D against the predicted model P00736: TM-score 0.98, RMSD 1.00 Å
- 2QY0 chain D against the predicted model P00736: TM-score 0.98, RMSD 1.00 Å
- 7MZT chain B against the predicted model P00736: TM-score 0.97, RMSD 1.00 Å
- 7MZT chain B against the predicted model P00736: TM-score 0.97, RMSD 1.00 Å
- 1MD8 chain A against the predicted model P00736: TM-score 0.97, RMSD 1.36 Å
- 1MD8 chain A against the predicted model P00736: TM-score 0.97, RMSD 1.36 Å
Elsewhere
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