MolNFT v1 · #14559 · protein
Monomeric structure of the zymogen of complement protease C1R
1MD7 · C1R complement serine protease: “Monomeric structure of the zymogen of complement protease C1R”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.61). MolNFT v1 #14559 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1MD7
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C1R complement serine protease
- EC
- 3.4.21.41
- UniProt
- P00736
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | C1R complement serine protease (EC 3.4.21.41) | protein | 304 | 10% helix, 30% strand | P00736 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.61 | 0.78 | 39 | empty |
| 2 | 174 | 0.45 | 0.74 | 21 | empty |
| 3 | 56 | 0.32 | 0.76 | 13 | empty |
Modifications
Observed in the structure: 5 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 1MD7 · Monomeric structure of the zymogen of complement protease C1r · the same entry in another collection · chain A against A, TM-score 1.00
- P00736 · AlphaFold monomer V2.0 prediction for complement C1R subcomponent (P00736) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00736
- Elsewhere: RCSB PDB 1MD7 · PDBe 1MD7 · UniProt P00736
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