UniProt P00722
Beta-galactosidase (P00722)
Beta-galactosidase (UniProt P00722), EC 3.2.1.23: 106 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00722
- Protein
- Beta-galactosidase
- EC
- 3.2.1.23
- Experimental structures
- 106
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 77 · 4 records with a druggable one
Structures
107 records of P00722 in the MolNFT archive: 106 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DP0 | E. COLI beta-galactosidase at 1.7 ångström | x-ray diffraction | A, B, C, D | — | — |
| 1DP0 | E. COLI beta-galactosidase at 1.7 ångström | x-ray diffraction | A, B, C, D | — | — |
| 1F4A | E. COLI (lacz) beta-galactosidase (ncs constrained monomer-orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1F4A | E. COLI (lacz) beta-galactosidase (ncs constrained monomer- orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1F4H | E. COLI (lacz) beta-galactosidase (orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1F4H | E. COLI (lacz) beta-galactosidase (orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1HN1 | E. COLI (lac Z) beta-galactosidase (orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1HN1 | E. COLI (lac Z) beta-galactosidase (orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1JYN | E. COLI (lacZ) BETA-GALACTOSIDASE (E537Q) IN COMPLEX WITH LACTOSE | x-ray diffraction | A, B, C, D | — | — |
| 1JYN | E. COLI (lacz) beta-galactosidase (E537Q) in complex with lactose | x-ray diffraction | A, B, C, D | — | — |
| 1JYV | E. COLI (lacZ) BETA-GALACTOSIDASE (E537Q) IN COMPLEX WITH ONPG | x-ray diffraction | A, B, C, D | — | — |
| 1JYV | E. COLI (lacz) beta-galactosidase (E537Q) in complex with onpg | x-ray diffraction | A, B, C, D | — | — |
| 1JYW | E. COLI (lacZ) BETA-GALACTOSIDASE (E537Q) IN COMPLEX WITH PNPG | x-ray diffraction | A, B, C, D | — | — |
| 1JYW | E. COLI (lacz) beta-galactosidase (E537Q) in complex with pnpg | x-ray diffraction | A, B, C, D | — | — |
| 1JYX | E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH IPTG | x-ray diffraction | A, B, C, D | — | — |
| 1JYX | E. COLI (lacz) beta-galactosidase in complex with iptg | x-ray diffraction | A, B, C, D | — | — |
| 1JZ2 | E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC) | x-ray diffraction | A, B, C, D | — | — |
| 1JZ2 | E. COLI (lacz) beta-galactosidase-trapped 2-F-galactosyl-enzyme intermediate (orthorhombic) | x-ray diffraction | A, B, C, D | — | — |
| 1JZ3 | E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-DEOXY-GALACTOSYL ENZYME INTERMEDIATE | x-ray diffraction | A, B, C, D | — | — |
| 1JZ3 | E. COLI (lacz) beta-galactosidase-trapped 2-deoxy-galactosyl enzyme intermediate | x-ray diffraction | A, B, C, D | — | — |
| 1JZ4 | E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-DEOXY-GALACTOSYL-ENZYME INTERMEDIATE (Low Bis-Tris) | x-ray diffraction | A, B, C, D | — | — |
| 1JZ4 | E. COLI (lacz) beta-galactosidase-trapped 2-deoxy-galactosyl-enzyme intermediate (low bis-tris) | x-ray diffraction | A, B, C, D | — | — |
| 1JZ5 | E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH D-GALCTOPYRANOSYL-1-ON | x-ray diffraction | A, B, C, D | — | — |
| 1JZ5 | E. COLI (lacz) beta-galactosidase in complex with D-galctopyranosyl-1- on | x-ray diffraction | A, B, C, D | — | — |
| 1JZ6 | E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE | x-ray diffraction | A, B, C, D | — | — |
| 1JZ6 | E. COLI (lacz) beta-galactosidase in complex with galacto- tetrazole | x-ray diffraction | A, B, C, D | — | — |
| 1JZ7 | E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTOSE | x-ray diffraction | A, B, C, D | — | — |
| 1JZ7 | E. COLI (lacz) beta-galactosidase in complex with galactose | x-ray diffraction | A, B, C, D | — | — |
| 1JZ8 | E. COLI (lacZ) BETA-GALACTOSIDASE (E537Q) IN COMPLEX WITH ALLOLACTOSE | x-ray diffraction | A, B, C, D | — | — |
| 1JZ8 | E. COLI (lacz) beta-galactosidase (E537Q) in complex with allolactose | x-ray diffraction | A, B, C, D | — | — |
| 1PX3 | E. COLI (lacz) beta-galactosidase (G794A) | x-ray diffraction | A, B, C, D | — | — |
| 1PX3 | E. COLI (lacz) beta-galactosidase (G794A) | x-ray diffraction | A, B, C, D | — | — |
| 1PX4 | E. COLI (lacz) beta-galactosidase (G794A) with iptg bound | x-ray diffraction | A, B, C, D | — | — |
| 1PX4 | E. COLI (lacz) beta-galactosidase (G794A) with iptg bound | x-ray diffraction | A, B, C, D | — | — |
| 3CZJ | E. COLI (lacZ) BETA-GALACTOSIDASE (N460T) IN COMPLEX WITH D-GALCTOPYRANOSYL-1-ONE | x-ray diffraction | A, B, C, D | — | — |
| 3CZJ | E. COLI (lacz) beta-galactosidase (N460T) in complex with D- galctopyranosyl-1-one | x-ray diffraction | A, B, C, D | — | — |
| 3DYM | E. coli (lacZ) beta-galactosidase (H418E) | x-ray diffraction | A, B, C, D | — | — |
| 3DYM | E. COLI (lacz) beta-galactosidase (H418E) | x-ray diffraction | A, B, C, D | — | — |
| 3DYO | E. coli (lacZ) beta-galactosidase (H418N) in complex with IPTG | x-ray diffraction | A, B, C, D | — | — |
| 3DYO | E. COLI (lacz) beta-galactosidase (H418N) in complex with iptg | x-ray diffraction | A, B, C, D | — | — |
| 3DYP | E. coli (lacZ) beta-galactosidase (H418N) | x-ray diffraction | A, B, C, D | — | — |
| 3DYP | E. COLI (lacz) beta-galactosidase (H418N) | x-ray diffraction | A, B, C, D | — | — |
| 3E1F | E.Coli (lacZ) beta-galactosidase (H418E) in complex with galactose | x-ray diffraction | 1, 2, 3, 4 | — | — |
| 3E1F | E.COLI (lacz) beta-galactosidase (H418E) in complex with galactose | x-ray diffraction | 1, 2, 3, 4 | — | — |
| 3J7H | Structure of beta-galactosidase at 3.2-A resolution obtained by cryo-electron microscopy | electron microscopy | A, B, C, D | — | — |
| 3J7H | Structure of beta-galactosidase at 3.2-a resolution obtained by cryo- electron microscopy | electron microscopy | A, B, C, D | — | — |
| 3SEP | E. coli (lacZ) beta-galactosidase (S796A) | x-ray diffraction | A, B, C, D | — | — |
| 3SEP | E. COLI (lacz) beta-galactosidase (S796A) | x-ray diffraction | A, B, C, D | — | — |
| 3T08 | E. coli (LacZ) beta-galactosidase (S796A) IPTG complex | x-ray diffraction | A, B, C, D | — | — |
| 3T08 | E. COLI (lacz) beta-galactosidase (S796A) iptg complex | x-ray diffraction | A, B, C, D | — | — |
| 3T09 | E. coli (LacZ) beta-galactosidase (S796A) galactonolactone complex | x-ray diffraction | A, B, C, D | — | — |
| 3T09 | E. COLI (lacz) beta-galactosidase (S796A) galactonolactone complex | x-ray diffraction | A, B, C, D | — | — |
| 3T0A | E. coli (LacZ) beta-galactosidase (S796T) | x-ray diffraction | A, B, C, D | — | — |
| 3T0A | E. COLI (lacz) beta-galactosidase (S796T) | x-ray diffraction | A, B, C, D | — | — |
| 3T0B | E. coli (LacZ) beta-galactosidase (S796T) IPTG complex | x-ray diffraction | A, B, C, D | — | — |
| 3T0B | E. COLI (lacz) beta-galactosidase (S796T) iptg complex | x-ray diffraction | A, B, C, D | — | — |
| 3T0D | E.coli (lacZ) beta-galactosidase (S796T) in complex with galactonolactone | x-ray diffraction | A, B, C, D | — | — |
| 3T0D | E.COLI (lacz) beta-galactosidase (S796T) in complex with galactonolactone | x-ray diffraction | A, B, C, D | — | — |
| 3T2O | E. coli (lacZ) beta-galactosidase (S796D) | x-ray diffraction | A, B, C, D | — | — |
| 3T2O | E. COLI (lacz) beta-galactosidase (S796D) | x-ray diffraction | A, B, C, D | — | — |
47 records more on the page itself.
Ligands
- MG · Magnesium ion · in 9 records
- NA · Sodium ion · in 9 records
- DVL · 3-(1,3-benzothiazol-2-yl)-2-[[4-[(2~{S},3~{R},4~{S}, 5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl) oxan-2-yl]oxyphenyl]methoxy]-5-methyl-benzaldehyde · in 2 records
- A1H05 · (2S,3R,4S)-2-[bis(oxidanyl)methyl]pyrrolidine-3,4-diol · in 1 record
- F4X · 8-[2-[(E)-2-[4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4, 5-tris(oxidanyl)oxan-2-yl]oxyphenyl]ethenyl]-3,3-dimethyl-indol-1-ium-1-yl]octanoic acid · in 1 record
- F6L · 4-[[2-[(E)-2-[4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3, 4,5-tris(oxidanyl)oxan-2-yl]oxyphenyl]ethenyl]-3,3-dimethyl-2H-indol-1-yl]methyl]benzoic acid · in 1 record
- PTQ · 2-phenylethyl 1-thio-beta-D-galactopyranoside · in 1 record
Experiment against prediction
- 3T2O chain D against the predicted model P00722: TM-score 1.00, RMSD 0.23 Å
- 3T2O chain D against the predicted model P00722: TM-score 1.00, RMSD 0.23 Å
- 1DP0 chain D against the predicted model P00722: TM-score 1.00, RMSD 0.27 Å
- 1DP0 chain D against the predicted model P00722: TM-score 1.00, RMSD 0.27 Å
- 3DYP chain D against the predicted model P00722: TM-score 1.00, RMSD 0.27 Å
- 3DYP chain D against the predicted model P00722: TM-score 1.00, RMSD 0.27 Å
- 1PX4 chain D against the predicted model P00722: TM-score 1.00, RMSD 0.28 Å
- 1PX4 chain D against the predicted model P00722: TM-score 1.00, RMSD 0.28 Å
- 3DYM chain D against the predicted model P00722: TM-score 1.00, RMSD 0.28 Å
- 3DYM chain D against the predicted model P00722: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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