UniProt P00639
Deoxyribonuclease-1 (P00639)
Deoxyribonuclease-1 (UniProt P00639), EC 3.1.21.1: 28 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00639
- Protein
- Deoxyribonuclease-1
- EC
- 3.1.21.1
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 22 · 4 records with a druggable one
Structures
29 records of P00639 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ATN | Atomic structure of the actin:DNASE I complex | x-ray diffraction | D | — | — |
| 1ATN | Atomic structure of the ACTIN:DNASE I complex | x-ray diffraction | D | — | — |
| 1DNK | The X-ray structure of the DNase I-D(GGTATACC)2 complex at 2.3 ångströms resolution | x-ray diffraction | A | — | — |
| 1DNK | The X-ray structure of the DNase I-D(GGTATACC)2 complex at 2.3 ångströms resolution | x-ray diffraction | A | — | — |
| 2A3Z | Ternary complex of the WH2 domain of WASP with Actin-DNAse I | x-ray diffraction | B | — | — |
| 2A3Z | Ternary complex of the WH2 domain of wasp with actin-DNase I | x-ray diffraction | B | — | — |
| 2A40 | Ternary complex of the WH2 domain of WAVE with Actin-DNAse I | x-ray diffraction | B, E | — | — |
| 2A40 | Ternary complex of the WH2 domain of wave with actin-DNase I | x-ray diffraction | B, E | — | — |
| 2A41 | Ternary complex of the WH2 Domain of WIP with Actin-DNAse I | x-ray diffraction | B | — | — |
| 2A41 | Ternary complex of the WH2 domain of wip with actin-DNase I | x-ray diffraction | B | — | — |
| 2A42 | Actin-DNAse I Complex | x-ray diffraction | B | — | — |
| 2A42 | Actin-DNase I complex | x-ray diffraction | B | — | — |
| 2D1K | Ternary complex of the WH2 domain of mim with actin-dnase I | x-ray diffraction | B | — | — |
| 2D1K | Ternary complex of the WH2 domain of mim with actin-DNase I | x-ray diffraction | B | — | — |
| 2DNJ | DNase I-induced DNA conformation. 2 ångströms structure of a DNase I-octamer complex | x-ray diffraction | A | — | — |
| 2DNJ | DNase I-induced DNA conformation. 2 ångströms structure of a DNase I- octamer complex | x-ray diffraction | A | — | — |
| 3CJC | Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with DNase I and Gelsolin-segment… | x-ray diffraction | D | — | — |
| 3CJC | Actin dimer cross-linked by V. cholerae martx toxin and complexed with DNase I and gelsolin-segment… | x-ray diffraction | D | — | — |
| 3DNI | Crystallographic refinement and structure of DNase I at 2 ångströms resolution | x-ray diffraction | A | — | — |
| 3DNI | Crystallographic refinement and structure of DNase I at 2 ångströms resolution | x-ray diffraction | A | — | — |
| 3W3D | Crystal structure of smooth muscle G actin DNase I complex | x-ray diffraction | B | — | — |
| 3W3D | Crystal structure of smooth muscle G actin DNase I complex | x-ray diffraction | B | — | — |
| 7NXV | Crystal structure of the complex of DNase I/G-actin/PPP1R15A_582-621 | x-ray diffraction | B, F | NAG, CA | 8 (best 0.72) |
| 7NXV | Crystal structure of the complex of DNase I/G-ACTIN/PPP1R15A_582-621 | x-ray diffraction | B, F | NAG, CA | — |
| 7NZM | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped… | electron microscopy | D | NAG | 3 (best 0.67) |
| 7NZM | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated EIF2ALPHA with trapped… | electron microscopy | D | NAG | — |
| 9FJU | Structure of the DNase I- and phalloidin-bound pointed end of F-actin (conformer 1) | electron microscopy | E, F | NAG, MG | 7 (best 0.71) |
| 9FJY | Structure of the DNase I- and phalloidin-bound pointed end of F-actin (conformer 2). | electron microscopy | E, F | NAG, MG | 4 (best 0.81) |
| P00639 | AlphaFold monomer V2.0 prediction for deoxyribonuclease-1 (P00639) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1DNK chain A against the predicted model P00639: TM-score 1.00, RMSD 0.34 Å
- 1DNK chain A against the predicted model P00639: TM-score 1.00, RMSD 0.34 Å
- 2DNJ chain A against the predicted model P00639: TM-score 1.00, RMSD 0.34 Å
- 2DNJ chain A against the predicted model P00639: TM-score 1.00, RMSD 0.34 Å
- 7NXV chain B against the predicted model P00639: TM-score 1.00, RMSD 0.36 Å
- 7NXV chain B against the predicted model P00639: TM-score 1.00, RMSD 0.36 Å
- 7NXV chain F against the predicted model P00639: TM-score 1.00, RMSD 0.40 Å
- 7NXV chain F against the predicted model P00639: TM-score 1.00, RMSD 0.40 Å
- 2A42 chain B against the predicted model P00639: TM-score 1.00, RMSD 0.47 Å
- 2A42 chain B against the predicted model P00639: TM-score 1.00, RMSD 0.47 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.