UniProt P00508
Aspartate aminotransferase (P00508)
Aspartate aminotransferase (UniProt P00508), EC 2.6.1.1: 28 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00508
- Protein
- Aspartate aminotransferase
- EC
- 2.6.1.1
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 8 · 1 record with a druggable one
Structures
29 records of P00508 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AKA | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A, B | — | — |
| 1AKA | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A, B | — | — |
| 1AKB | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A | — | — |
| 1AKB | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A | — | — |
| 1AKC | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A | — | — |
| 1AKC | Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its… | x-ray diffraction | A | — | — |
| 1AMA | Domain closure in mitochondrial aspartate aminotransferase | x-ray diffraction | A | — | — |
| 1AMA | Domain closure in mitochondrial aspartate aminotransferase | x-ray diffraction | A | — | — |
| 1IVR | Structure of aspartate aminotransferase | x-ray diffraction | A | — | — |
| 1IVR | Structure of aspartate aminotransferase | x-ray diffraction | A | — | — |
| 1MAP | Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in… | x-ray diffraction | A | — | — |
| 1MAP | Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in… | x-ray diffraction | A | — | — |
| 1MAQ | Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in… | x-ray diffraction | A | — | — |
| 1MAQ | Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in… | x-ray diffraction | A | — | — |
| 1OXO | Aspartate aminotransferase, H-asp complex, open conformation | x-ray diffraction | A, B | — | — |
| 1OXO | Aspartate aminotransferase, H-asp complex, open conformation | x-ray diffraction | A, B | — | — |
| 1OXP | Aspartate aminotransferase, H-asp complex, closed conformation | x-ray diffraction | A | — | — |
| 1OXP | Aspartate aminotransferase, H-asp complex, closed conformation | x-ray diffraction | A | — | — |
| 1TAR | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 1TAR | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 1TAS | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 1TAS | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 1TAT | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 1TAT | Crystalline mitochondrial aspartate aminotransferase exists in only two conformations | x-ray diffraction | A, B | — | — |
| 7AAT | X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase | x-ray diffraction | A, B | PLP | — |
| 8AAT | X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase | x-ray diffraction | A, B | PLP | — |
| 9AAT | X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase | x-ray diffraction | A, B | PMP | 8 (best 0.74) |
| 9AAT | X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase | x-ray diffraction | A, B | PMP | — |
| P00508 | AlphaFold monomer V2.0 prediction for aspartate aminotransferase, mitochondrial (P00508) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1AKA chain B against the predicted model P00508: TM-score 0.99, RMSD 0.64 Å
- 1OXO chain B against the predicted model P00508: TM-score 0.99, RMSD 0.65 Å
- 1OXO chain B against the predicted model P00508: TM-score 0.99, RMSD 0.65 Å
- 8AAT chain B against the predicted model P00508: TM-score 0.99, RMSD 0.65 Å
- 7AAT chain B against the predicted model P00508: TM-score 0.99, RMSD 0.66 Å
- 9AAT chain B against the predicted model P00508: TM-score 0.99, RMSD 0.67 Å
- 9AAT chain B against the predicted model P00508: TM-score 0.99, RMSD 0.67 Å
- 1TAR chain B against the predicted model P00508: TM-score 0.99, RMSD 0.73 Å
- 1TAR chain B against the predicted model P00508: TM-score 0.99, RMSD 0.73 Å
- 1TAR chain A against the predicted model P00508: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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