UniProt P00424
Cytochrome c oxidase subunit 5A, mitochondrial (P00424)
Cytochrome c oxidase subunit 5A, mitochondrial (UniProt P00424), EC 1.9.3.1: 13 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- P00424
- Protein
- Cytochrome c oxidase subunit 5A, mitochondrial
- EC
- 1.9.3.1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 20 · 7 records with a druggable one
Structures
14 records of P00424 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | e | — | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | e, q | CDL, PCF, PEF | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | e, q | CDL, PCF, PEF | — |
| 6YMX | CIII2/CIV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | e | CN3, PTY, PCF | 1 (best 0.78) |
| 6YMX | CIII2/CIV respiratory supercomplex from saccharomyces cerevisiae | electron microscopy | e | CN3, PTY, PCF | — |
| 6YMY | Cytochrome c oxidase from Saccharomyces cerevisiae | electron microscopy | e | PTY, CN3, PCF | 3 (best 0.75) |
| 6YMY | Cytochrome C oxidase from saccharomyces cerevisiae | electron microscopy | e | PTY, CN3, PCF | — |
| 7Z10 | Monomeric respiratory complex IV isolated from S. cerevisiae | electron microscopy | e | — | 3 (best 0.57) |
| 8DH6 | Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid… | electron microscopy | e | PEF | 5 (best 0.66) |
| 8DH6 | Cryo-EM structure of saccharomyces cerevisiae cytochrome C oxidase (complex IV) extracted in lipid… | electron microscopy | e | PEF | — |
| 8E7S | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | electron microscopy | W, w | CDL, PEF, PCF | 4 (best 0.86) |
| 8EC0 | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | electron microscopy | W | PGT, PEF, PCF | 2 (best 0.86) |
| 9ETZ | III2IV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | e | CDL, PEF, PCF | 2 (best 0.77) |
| P00424 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 5A, mitochondrial (P00424) | predicted | A | — | — |
Ligands
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 9 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 7 records
- CDL · Cardiolipin · in 4 records
- CN3 · (2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate · in 4 records
- PTY · Phosphatidylethanolamine · in 4 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
Experiment against prediction
- 6HU9 chain q against the predicted model P00424: TM-score 0.96, RMSD 0.85 Å
- 6HU9 chain q against the predicted model P00424: TM-score 0.96, RMSD 0.85 Å
- 6HU9 chain e against the predicted model P00424: TM-score 0.96, RMSD 0.86 Å
- 6HU9 chain e against the predicted model P00424: TM-score 0.96, RMSD 0.86 Å
- 8DH6 chain e against the predicted model P00424: TM-score 0.96, RMSD 0.88 Å
- 8DH6 chain e against the predicted model P00424: TM-score 0.96, RMSD 0.88 Å
- 6YMX chain e against the predicted model P00424: TM-score 0.95, RMSD 0.94 Å
- 6YMX chain e against the predicted model P00424: TM-score 0.95, RMSD 0.94 Å
- 6YMY chain e against the predicted model P00424: TM-score 0.95, RMSD 0.99 Å
- 6YMY chain e against the predicted model P00424: TM-score 0.95, RMSD 0.99 Å
Elsewhere
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