UniProt P00410
Cytochrome c oxidase subunit 2 (P00410)
Cytochrome c oxidase subunit 2 (UniProt P00410), EC 1.9.3.1, 7.1.1.9: 17 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00410
- Protein
- Cytochrome c oxidase subunit 2
- EC
- 1.9.3.1, 7.1.1.9
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 68 · 9 records with a druggable one
Structures
18 records of P00410 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | b | HEA, CUA | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | b, n | HEA, MG, PEF, CUA | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | b, n | HEA, MG, PEF, CUA | — |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | b, o | HEA, MG, CUA, PEF | 5 (best 0.91) |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | b, o | HEA, MG, CUA, PEF | — |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | b | HEA, MG, CUA, PEF | — |
| 6YMX | CIII2/CIV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | b | HEA, CUA, PTY, PCF | 3 (best 0.91) |
| 6YMX | CIII2/CIV respiratory supercomplex from saccharomyces cerevisiae | electron microscopy | b | HEA, CUA, PTY, PCF | — |
| 6YMY | Cytochrome c oxidase from Saccharomyces cerevisiae | electron microscopy | b | HEA, PTY, CUA, PCF | 10 (best 0.91) |
| 6YMY | Cytochrome C oxidase from saccharomyces cerevisiae | electron microscopy | b | HEA, PTY, CUA, PCF | — |
| 7Z10 | Monomeric respiratory complex IV isolated from S. cerevisiae | electron microscopy | b | HEA, MG, CUA | 11 (best 0.91) |
| 7Z10 | Monomeric respiratory complex IV isolated from S. cerevisiae | electron microscopy | b | HEA, MG, CUA | 11 (best 0.91) |
| 8DH6 | Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid… | electron microscopy | b | MG, HEA, PEF, CU | 11 (best 0.91) |
| 8DH6 | Cryo-EM structure of saccharomyces cerevisiae cytochrome C oxidase (complex IV) extracted in lipid… | electron microscopy | b | MG, HEA, PEF, CU | — |
| 8E7S | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | electron microscopy | P, p | HEA, CUA, PEF | 9 (best 0.90) |
| 8EC0 | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | electron microscopy | P | HEA, CUA, PEF | 3 (best 0.89) |
| 9ETZ | III2IV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | b | HEA, MG, CUA, PEF | 5 (best 0.88) |
| P00410 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 2 (P00410) | predicted | A | — | — |
Ligands
- HEA · Heme-A · in 17 records
- CUA · Dinuclear copper ion · in 15 records
- MG · Magnesium ion · in 10 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 10 records
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 4 records
- PTY · Phosphatidylethanolamine · in 4 records
- CU · Copper (II) ion · in 2 records
Experiment against prediction
- 6HU9 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.64 Å
- 6HU9 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.64 Å
- 6HU9 chain n against the predicted model P00410: TM-score 0.99, RMSD 0.63 Å
- 6HU9 chain n against the predicted model P00410: TM-score 0.99, RMSD 0.63 Å
- 8DH6 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.63 Å
- 8DH6 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.63 Å
- 7Z10 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.68 Å
- 7Z10 chain b against the predicted model P00410: TM-score 0.99, RMSD 0.68 Å
- 6T0B chain o against the predicted model P00410: TM-score 0.98, RMSD 0.75 Å
- 6T0B chain o against the predicted model P00410: TM-score 0.98, RMSD 0.75 Å
Elsewhere
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