UniProt P00392
Mercuric reductase (P00392)
Mercuric reductase (UniProt P00392), EC 1.16.1.1: 12 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00392
- Protein
- Mercuric reductase
- EC
- 1.16.1.1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 19 · 7 records with a druggable one
Structures
13 records of P00392 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZK7 | Crystal Structure of Tn501 MerA | x-ray diffraction | A | SO4, FAD | 3 (best 0.78) |
| 1ZK7 | Crystal structure of TN501 mera | x-ray diffraction | A | SO4, FAD | 3 (best 0.78) |
| 1ZX9 | Crystal Structure of Tn501 MerA | x-ray diffraction | A | FAD | 2 (best 0.78) |
| 1ZX9 | Crystal structure of TN501 mera | x-ray diffraction | A | FAD | 2 (best 0.78) |
| 2KT2 | Structure of NmerA, the N-terminal HMA domain of Tn501 Mercuric Reductase | solution nmr | A | — | — |
| 2KT2 | Structure of nmera, the N-terminal hma domain of TN501 mercuric reductase | solution nmr | A | — | — |
| 2KT3 | Structure of Hg-NmerA, Hg(II) complex of the N-terminal domain of Tn501 Mercuric Reductase | solution nmr | A | HG | — |
| 2KT3 | Structure of hg-nmera, HG(II) complex of the N-terminal domain of TN501 mercuric reductase | solution nmr | A | — | — |
| 4K7Z | Crystal structure of the C136(42)A/C141(47)A double mutant of Tn501 MerA in complex with NADP and… | x-ray diffraction | A | FAD, NAP, HG, SO4, UNX | 3 (best 0.78) |
| 4K7Z | Crystal structure of the C136(42)A/C141(47)A double mutant of TN501 mera in complex with NADP and… | x-ray diffraction | A | — | — |
| 4K8D | Crystal structure of the C558(464)A/C559(465)A double mutant of Tn501 MerA in complex with NADPH… | x-ray diffraction | A | SO4, FAD, NDP, UNX | 2 (best 0.79) |
| 4K8D | Crystal structure of the C558(464)A/C559(465)A double mutant of TN501 mera in complex with NADPH… | x-ray diffraction | A | — | — |
| P00392 | AlphaFold monomer V2.0 prediction for mercuric reductase (P00392) | predicted | A | — | 4 (best 0.78) |
Ligands
- FAD · Flavin-adenine dinucleotide · in 6 records
- SO4 · Sulfate ion · in 4 records
- HG · Mercury (II) ion · in 2 records
- UNX · Unknown atom or ion · in 2 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
Experiment against prediction
- 4K7Z chain A against the predicted model P00392: TM-score 1.00, RMSD 0.21 Å
- 4K7Z chain A against the predicted model P00392: TM-score 1.00, RMSD 0.21 Å
- 4K8D chain A against the predicted model P00392: TM-score 1.00, RMSD 0.25 Å
- 4K8D chain A against the predicted model P00392: TM-score 1.00, RMSD 0.25 Å
- 1ZX9 chain A against the predicted model P00392: TM-score 1.00, RMSD 0.44 Å
- 1ZX9 chain A against the predicted model P00392: TM-score 1.00, RMSD 0.44 Å
- 1ZK7 chain A against the predicted model P00392: TM-score 1.00, RMSD 0.58 Å
- 1ZK7 chain A against the predicted model P00392: TM-score 1.00, RMSD 0.58 Å
- 2KT3 chain A against the predicted model P00392: TM-score 0.80, RMSD 1.92 Å
- 2KT3 chain A against the predicted model P00392: TM-score 0.80, RMSD 1.92 Å
Elsewhere
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