UniProt O96935
M1 family aminopeptidase (O96935)
M1 family aminopeptidase (UniProt O96935), EC 3.4.11.-: 79 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O96935
- Protein
- M1 family aminopeptidase
- EC
- 3.4.11.-
- Experimental structures
- 79
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 67 · 6 records with a druggable one
Structures
80 records of O96935 in the MolNFT archive: 79 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3EBG | Structure of the M1 Alanylaminopeptidase from malaria | x-ray diffraction | A | — | — |
| 3EBG | Structure of the M1 alanylaminopeptidase from malaria | x-ray diffraction | A | — | — |
| 3EBH | Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin | x-ray diffraction | A | — | — |
| 3EBH | Structure of the M1 alanylaminopeptidase from malaria complexed with bestatin | x-ray diffraction | A | — | — |
| 3EBI | Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide… | x-ray diffraction | A | — | — |
| 3EBI | Structure of the M1 alanylaminopeptidase from malaria complexed with the phosphinate dipeptide… | x-ray diffraction | A | — | — |
| 3Q43 | X-ray crystal structure of PfA-M1 bound to bestatin derivative 15 | x-ray diffraction | A | — | — |
| 3Q43 | X-ray crystal structure of pfa-M1 bound to bestatin derivative 15 | x-ray diffraction | A | — | — |
| 3Q44 | X-ray crystal structure of PfA-M1 bound to Bestatin derivative 16 | x-ray diffraction | A | — | — |
| 3Q44 | X-ray crystal structure of pfa-M1 bound to bestatin derivative 16 | x-ray diffraction | A | — | — |
| 3T8V | A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family… | x-ray diffraction | A | — | — |
| 3T8V | A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family… | x-ray diffraction | A | — | — |
| 4J3B | A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic… | x-ray diffraction | A | — | — |
| 4J3B | A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic… | x-ray diffraction | A | — | — |
| 4K5L | Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5L | Phosphonic arginine mimetics as inhibitors of the M1 aminopeptidases from plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5M | Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5M | Phosphonic arginine mimetics as inhibitors of the M1 aminopeptidases from plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5N | Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5N | Phosphonic arginine mimetics as inhibitors of the M1 aminopeptidases from plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5O | Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5O | Phosphonic arginine mimetics as inhibitors of the M1 aminopeptidases from plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5P | Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 4K5P | Phosphonic arginine mimetics as inhibitors of the M1 aminopeptidases from plasmodium falciparum | x-ray diffraction | A | — | — |
| 4R5T | Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4R5T | Structure of the M1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4R5V | Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4R5V | Structure of the M1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4R5X | Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4R5X | Structure of the M1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based… | x-ray diffraction | A | — | — |
| 4X2U | X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the… | x-ray diffraction | A | — | — |
| 4X2U | X-ray crystal structure of the orally available aminopeptidase inhibitor, tosedostat, bound to the… | x-ray diffraction | A | — | — |
| 4ZQT | Crystal structure of PfA-M1 with virtual ligand inhibitor | x-ray diffraction | A | 4QP, ZN, MG | 13 (best 0.80) |
| 4ZQT | Crystal structure of pfa-M1 with virtual ligand inhibitor | x-ray diffraction | A | — | — |
| 4ZW3 | X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b | x-ray diffraction | A | — | — |
| 4ZW3 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 9B | x-ray diffraction | A | — | — |
| 4ZW5 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 9F | x-ray diffraction | A | — | — |
| 4ZW6 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 9Q | x-ray diffraction | A | — | — |
| 4ZW7 | X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m | x-ray diffraction | A | — | — |
| 4ZW7 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 9M | x-ray diffraction | A | — | — |
| 4ZW8 | X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r | x-ray diffraction | A | — | — |
| 4ZW8 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 9R | x-ray diffraction | A | — | — |
| 4ZX3 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 10B | x-ray diffraction | A | — | — |
| 4ZX4 | X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o | x-ray diffraction | A | — | — |
| 4ZX4 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 10O | x-ray diffraction | A | — | — |
| 4ZX5 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 10Q | x-ray diffraction | A | — | — |
| 4ZX6 | X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s | x-ray diffraction | A | — | — |
| 4ZX6 | X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 10S | x-ray diffraction | A | — | — |
| 5XM7 | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, 89X | — |
| 5XM7 | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, 89X | — |
| 5Y19 | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG | — |
| 5Y19 | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG | — |
| 5Y1H | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | MG, ZN, E8C | 9 (best 0.79) |
| 5Y1H | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | MG, ZN, E8C | — |
| 5Y1K | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, B1B | — |
| 5Y1Q | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, 8L0 | — |
| 5Y1R | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG | — |
| 5Y1S | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, E8F, E8R | — |
| 5Y1T | Crystal structure of plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG, E8G | — |
| 5Y1V | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with… | x-ray diffraction | A | ZN, MG | — |
20 records more on the page itself.
Ligands
- MG · Magnesium ion · in 32 records
- ZN · Zinc ion · in 32 records
- PO4 · Phosphate ion · in 6 records
- 89X · (2S)-4-methyl-N-[(1R)-2-(oxidanylamino)-2-oxidanylidene-1-phenyl-ethyl]-2-[(phenylmethyl) carbamoylamino]pentanamide · in 2 records
- BB2 · Actinonin · in 2 records
- E8C · (2R)-2-[[2,4-bis(fluoranyl) phenyl]methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 2 records
- 4QP · (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid · in 1 record
- 8L0 · (2S)-2-[(3-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 1 record
- 8N3 · (2R)-4-methyl-2-[(3-methylphenyl)methylcarbamoylamino]-N-oxidanyl-pentanamide · in 1 record
- B1B · (2S)-2-[(2-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 1 record
- BYW · 2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-2-methylpropanamide · in 1 record
- E8F · (2S)-2-[(3,4-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 1 record
- E8G · (2S)-2-[(2,3-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 1 record
- E8R · (2R)-2-[(3,4-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide · in 1 record
- J0Y · (2R)-2,3,3,3-tetrafluoro-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]propanamide · in 1 record
- X0I · (2R)-2-(cyclopentylcarbamamido)-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide · in 1 record
- X10 · N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-N~2~-phenylglycinamide · in 1 record
Experiment against prediction
- 5XM7 chain A against the predicted model O96935: TM-score 1.00, RMSD 0.29 Å
- 5XM7 chain A against the predicted model O96935: TM-score 1.00, RMSD 0.29 Å
- 5Y1H chain A against the predicted model O96935: TM-score 1.00, RMSD 0.29 Å
- 5Y1H chain A against the predicted model O96935: TM-score 1.00, RMSD 0.29 Å
- 5Y1T chain A against the predicted model O96935: TM-score 1.00, RMSD 0.29 Å
- 5Y3I chain A against the predicted model O96935: TM-score 1.00, RMSD 0.30 Å
- 5Y1W chain A against the predicted model O96935: TM-score 1.00, RMSD 0.30 Å
- 5Y1S chain A against the predicted model O96935: TM-score 1.00, RMSD 0.30 Å
- 5Y1Q chain A against the predicted model O96935: TM-score 1.00, RMSD 0.30 Å
- 5Y1K chain A against the predicted model O96935: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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