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Ligand · 4TL

4TL · N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide

4TL, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide (C19 H19 F3 N2 O3, 380.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…

Component
4TL
Formula
C19 H19 F3 N2 O3
Class
ligand
Structures
4
PDB entries
2

Binding sites

4TL in 4 structures; the first of them:

  • 4ZX4 · X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o · 4TL A1101 · binds LEU304, THR305, GLN317, GLU319, ALA320, ASN458, VAL459, GLY460 and 13 more
  • 4ZY2 · X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10o · 4TL A1008 · binds LYS374, ASP379, LYS386, GLY390, SER391, MET392, LEU395, MET396 and 17 more
  • 4ZX4 · X-ray crystal structure of pfa-M1 in complex with hydroxamic acid- based inhibitor 10O · 4TL A1101 · binds LEU304, THR305, GLN317, GLU319, ALA320, ASN458, VAL459, GLY460 and 13 more
  • 4ZY2 · X-ray crystal structure of pfa-M17 in complex with hydroxamic acid- based inhibitor 10O · 4TL A1008 · binds LYS374, ASP379, LYS386, GLY390, SER391, MET392, LEU395, MET396 and 17 more

Residues it binds most

GLY 26, LEU 26, ASP 24, MET 26, THR 26, LYS 24, PHE 24, SER 24, ALA 26, GLU 26 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • MG · Magnesium ion
  • CO3 · Carbonate ion
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • 1PE · Pentaethylene glycol
  • GOL · Glycerol

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