UniProt O95180
Voltage-dependent T-type calcium channel subunit alpha-1H (O95180)
Voltage-dependent T-type calcium channel subunit alpha-1H (UniProt O95180): 4 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O95180
- Protein
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 77 · 4 records with a druggable one
Structures
5 records of O95180 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 9AYH | Cryo-EM structure of human Cav3.2 with TTA-A2 | electron microscopy | A | A1AHH, NAG, CA, LPE, Y01, JL3 | 19 (best 0.85) |
| 9AYJ | Cryo-EM structure of human Cav3.2 with TTA-P2 | electron microscopy | A | A1AHI, NAG, CA, LPE, Y01, JL3 | 20 (best 0.85) |
| 9AYK | Cryo-EM structure of human Cav3.2 with ML218 | electron microscopy | A | A1AHJ, NAG, CA, LPE, Y01, JL3 | 19 (best 0.85) |
| 9AYL | Cryo-EM structure of human Cav3.2 with ACT-709478 | electron microscopy | A | A1AHK, NAG, CA, LPE, Y01, JL3 | 19 (best 0.83) |
| O95180 | AlphaFold monomer V2.0 prediction for voltage-dependent T-type calcium channel subunit alpha-1H… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- JL3 · [(2~{R})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate · in 4 records
- LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- A1AHH · 2-(4-cyclopropylphenyl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide · in 1 record
- A1AHI · 3,5-dichloro-N-[(1-{[(4S)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide · in 1 record
- A1AHJ · 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide · in 1 record
- A1AHK · N-{1-[(5-cyanopyridin-2-yl)methyl]-1H-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide · in 1 record
Experiment against prediction
- 9AYK chain A against the predicted model O95180: TM-score 0.98, RMSD 1.47 Å
- 9AYJ chain A against the predicted model O95180: TM-score 0.98, RMSD 1.48 Å
- 9AYH chain A against the predicted model O95180: TM-score 0.98, RMSD 1.48 Å
- 9AYL chain A against the predicted model O95180: TM-score 0.98, RMSD 1.52 Å
Elsewhere
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