UniProt O87605
Cytochrome P450 monooxygenase PikC (O87605)
Cytochrome P450 monooxygenase PikC (UniProt O87605), EC 1.14.15.33: 34 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O87605
- Protein
- Cytochrome P450 monooxygenase PikC
- EC
- 1.14.15.33
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 16 · 5 records with a druggable one
Structures
35 records of O87605 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BVJ | Ligand-free structure of cytochrome P450 PikC (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2BVJ | Ligand-free structure of cytochrome P450 pikc (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2C6H | Crystal structure of YC-17-bound cytochrome P450 PikC (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2C6H | Crystal structure of yc-17-bound cytochrome P450 pikc (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2C7X | Crystal structure of narbomycin-bound cytochrome P450 PikC (CYP107L1) | x-ray diffraction | A | — | — |
| 2C7X | Crystal structure of narbomycin-bound cytochrome P450 pikc (CYP107L1) | x-ray diffraction | A | — | — |
| 2CA0 | Crystal structure of YC-17-bound cytochrome P450 PikC (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2CA0 | Crystal structure of yc-17-bound cytochrome P450 pikc ( CYP107L1) | x-ray diffraction | A, B | — | — |
| 2CD8 | Crystal structure of YC-17-bound cytochrome P450 PikC (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2CD8 | Crystal structure of yc-17-bound cytochrome P450 pikc (CYP107L1) | x-ray diffraction | A, B | — | — |
| 2VZ7 | Crystal structure of the YC-17-bound PikC D50N mutant | x-ray diffraction | A, B | — | — |
| 2VZ7 | Crystal structure of the yc-17-bound pikc D50N mutant | x-ray diffraction | A, B | — | — |
| 2VZM | Crystal structure of the narbomycin-bound PikC D50N mutant | x-ray diffraction | A, B | — | — |
| 2VZM | Crystal structure of the narbomycin-bound pikc D50N mutant | x-ray diffraction | A, B | — | — |
| 2WHW | Selective oxidation of carbolide C-H bonds by engineered macrolide P450 monooxygenase | x-ray diffraction | A, B | — | — |
| 2WHW | Selective oxidation of carbolide C-H bonds by engineered macrolide P450 monooxygenase | x-ray diffraction | A, B | — | — |
| 2WI9 | Selective oxidation of carbolide C-H bonds by engineered macrolide P450 monooxygenase | x-ray diffraction | A, B | — | — |
| 2WI9 | Selective oxidation of carbolide C-H bonds by engineered macrolide P450 monooxygenase | x-ray diffraction | A, B | — | — |
| 3ZK5 | PikC D50N mutant bound to the 10-DML analog with the 3-(N,N-dimethylamino)ethanoate anchoring group | x-ray diffraction | A, B | — | — |
| 3ZK5 | Pikc D50N mutant bound to the 10-dml analog with the 3-(N,N-DIMETHYLAMINO)ETHANOATE anchoring group | x-ray diffraction | A, B | — | — |
| 3ZPI | PikC D50N mutant in P21 space group | x-ray diffraction | A, B | — | — |
| 3ZPI | Pikc D50N mutant in P21 space group | x-ray diffraction | A, B | — | — |
| 4B7D | PikC bound to the 10-DML analog with the 3-(N,N-dimethylamino) propanoate anchoring group | x-ray diffraction | A, B | — | — |
| 4B7D | Pikc bound to the 10-dml analog with the 3-(N,N-dimethylamino) propanoate anchoring group | x-ray diffraction | A, B | — | — |
| 4B7S | PikC D50N mutant bound to the 10-DML analog with the 3-(N,N- dimethylamino)propanoate anchoring… | x-ray diffraction | A, B | — | — |
| 4B7S | Pikc D50N mutant bound to the 10-dml analog with the 3-(N,N- DIMETHYLAMINO)PROPANOATE anchoring… | x-ray diffraction | A, B | — | — |
| 4BF4 | PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 4BF4 | Pikc D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 4UMZ | PikC D50N mutant in complex with the engineered substrate mimic bearing a… | x-ray diffraction | A, B | — | — |
| 4UMZ | Pikc D50N mutant in complex with the engineered substrate mimic bearing a… | x-ray diffraction | A, B | — | — |
| 7XBM | Crystal Structure of cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine… | x-ray diffraction | A, B | HEM, SO4 | 4 (best 0.86) |
| 7XBN | Crystal Structure of YC-17-bound cytochrome P450 PikC with the unnatural amino acid… | x-ray diffraction | A, B | HEM, PXI | 4 (best 0.86) |
| 7XBO | Crystal Structure of 10-dml-bound cytochrome P450 PikC with the unnatural amino acid… | x-ray diffraction | A, B | HEM, E4H | 4 (best 0.86) |
| 8GUE | Crystal Structure of narbomycin-bound cytochrome P450 PikC with the unnatural amino acid… | x-ray diffraction | A, B | HEM, NRB, SO4 | 3 (best 0.86) |
| O87605 | AlphaFold monomer V2.0 prediction for cytochrome P450 monooxygenase pikc (O87605) | predicted | A | — | 1 (best 0.85) |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 4 records
- SO4 · Sulfate ion · in 2 records
- E4H · (3R,4S,5S,7R,9E,11R,12R)-12-ethyl-4-hydroxy-3,5,7,11-tetramethyloxacyclododec-9-ene-2,8-dione · in 1 record
- NRB · Narbomycin · in 1 record
- PXI · 4-{[4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-12-ethyl-3,5,7,11-tetramethyloxacyclododec-9-ene-2,8-dione · in 1 record
Experiment against prediction
- 2WHW chain A against the predicted model O87605: TM-score 0.99, RMSD 0.60 Å
- 2WHW chain A against the predicted model O87605: TM-score 0.99, RMSD 0.60 Å
- 7XBM chain A against the predicted model O87605: TM-score 0.99, RMSD 0.60 Å
- 7XBN chain A against the predicted model O87605: TM-score 0.99, RMSD 0.61 Å
- 7XBO chain A against the predicted model O87605: TM-score 0.99, RMSD 0.63 Å
- 4UMZ chain B against the predicted model O87605: TM-score 0.99, RMSD 0.63 Å
- 4UMZ chain B against the predicted model O87605: TM-score 0.99, RMSD 0.63 Å
- 4UMZ chain A against the predicted model O87605: TM-score 0.99, RMSD 0.64 Å
- 4UMZ chain A against the predicted model O87605: TM-score 0.99, RMSD 0.64 Å
- 2C6H chain A against the predicted model O87605: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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