UniProt O79882
NADH-ubiquinone oxidoreductase chain 6 (O79882)
NADH-ubiquinone oxidoreductase chain 6 (UniProt O79882), EC 1.6.5.3, 7.1.1.2: 71 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 176 pockets. Binding sites, druggability and experiment against…
- UniProt
- O79882
- Protein
- NADH-ubiquinone oxidoreductase chain 6
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 71
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 176 · 51 records with a druggable one
Structures
72 records of O79882 in the MolNFT archive: 71 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | k, l | — | — |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | m | PEE | 3 (best 0.90) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | m | CDL, PEE, PLX | 3 (best 0.85) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | m | CDL, PEE, PLX | — |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | m | PLX, PEE | 3 (best 0.91) |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | m | PLX, PEE | — |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | m | PEE, PLX, CDL | 3 (best 0.91) |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | m | PEE, PLX, CDL | — |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | m | PLX, PEE | 4 (best 0.90) |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7V2H | Active state complex I from DQ-NADH dataset | electron microscopy | m | CDL, PLX, PEE | 5 (best 0.89) |
| 7V2H | Active state complex I from dq-NADH dataset | electron microscopy | m | CDL, PLX, PEE | — |
| 7V2K | Deactive state complex I from DQ-NADH dataset | electron microscopy | m | PLX, PEE | 5 (best 0.88) |
| 7V2K | Deactive state complex I from dq-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | m | CDL, PEE, PLX | 3 (best 0.89) |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | m | CDL, PEE, PLX | — |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | m | PLX, PEE | 4 (best 0.91) |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7V31 | Active state complex I from rote dataset | electron microscopy | m | PEE, PLX, CDL | 3 (best 0.90) |
| 7V31 | Active state complex I from rotenone dataset | electron microscopy | m | PEE, PLX, CDL | — |
| 7V32 | Deactive state complex I from rotenone dataset | electron microscopy | m | PLX, PEE | — |
| 7V33 | Active state complex I from rote -NADH dataset | electron microscopy | m | PEE, CDL, PLX | 3 (best 0.86) |
| 7V33 | Active state complex I from rotenone-NADH dataset | electron microscopy | m | PEE, CDL, PLX | — |
| 7V3M | Deactive state complex I from rote -NADH dataset | electron microscopy | m | PEE, PLX | — |
| 7V3M | Deactive state complex I from rotenone-NADH dataset | electron microscopy | m | PEE, PLX | — |
| 7VBL | Membrane arm of active state ci from dq-NADH dataset | electron microscopy | m | PEE, CDL, PLX | — |
| 7VBP | Membrane arm of deactive state CI from DQ-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7VBP | Membrane arm of deactive state ci from dq-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7VC0 | Membrane arm of active state ci from rotenone-NADH dataset | electron microscopy | m | PEE, PLX, CDL | — |
| 7VWL | Membrane arm of deactive state CI from rote -NADH dataset | electron microscopy | m | PLX, PEE | 4 (best 0.90) |
| 7VWL | Membrane arm of deactive state ci from rotenone-NADH dataset | electron microscopy | m | PLX, PEE | — |
| 7VXS | Membrane arm of active state CI from Q10 dataset | electron microscopy | m | PEE, PLX, CDL | 5 (best 0.84) |
| 7VY1 | Membrane arm of deactive state CI from Q10 dataset | electron microscopy | m | PEE, PLX | 3 (best 0.89) |
| 7VY9 | Membrane arm of active state CI from Q10-NADH dataset | electron microscopy | m | PEE, PLX, CDL | 3 (best 0.91) |
| 7VYE | Membrane arm of deactive state CI from Q10-NADH dataset | electron microscopy | m | PLX, PEE | 4 (best 0.89) |
| 7VYS | Membrane arm of active state CI from Q1-NADH dataset | electron microscopy | m | PEE, PLX, CDL | 5 (best 0.90) |
| 7VZW | Active state CI from Q10 dataset, Subclass 2 | electron microscopy | m | PEE, PLX, CDL | 3 (best 0.91) |
| 7W0H | Deactive state CI from Q10 dataset, Subclass 2 | electron microscopy | m | PEE, PLX | 4 (best 0.89) |
| 7W1O | Deactive state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | m | PLX, PEE | 4 (best 0.89) |
| 7W1T | Active state CI from Rote dataset, Subclass 1 | electron microscopy | m | PEE, PLX, CDL | 3 (best 0.90) |
| 7W1U | Active state CI from Rote dataset, Subclass 2 | electron microscopy | m | PEE, PLX | 3 (best 0.85) |
| 7W1V | Active state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | m | CDL, PEE, PLX | 3 (best 0.89) |
| 7W20 | Active state CI from Rote -NADH dataset, Subclass 3 | electron microscopy | m | PEE, PLX, CDL | 4 (best 0.87) |
| 7W2K | Deactive state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | m | PLX, PEE | 3 (best 0.90) |
| 7W2L | Deactive state CI from Rote -NADH dataset, Subclass 2 | electron microscopy | m | PLX, PEE | 3 (best 0.91) |
| 7W2R | Active state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | m | PEE, CDL, PLX | 3 (best 0.87) |
| 7W2U | Active state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | m | PEE, CDL, PLX | 3 (best 0.84) |
| 7W2Y | Active state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | m | CDL, PEE, PLX | 4 (best 0.87) |
| 7W32 | Deactive state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | m | PLX, PEE | 5 (best 0.90) |
| 7W35 | Deactive state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | m | PLX, PEE | 4 (best 0.89) |
| 7W4C | Active state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | m | CDL, PEE, PLX | 3 (best 0.87) |
| 7W4E | Active state CI from Q1-NADH dataset, Subclass 3 | electron microscopy | m | CDL, PEE, PLX | 3 (best 0.86) |
| 7W4G | Active state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | m | PEE, PLX, CDL | 5 (best 0.86) |
| 7W4J | Deactive state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | m | PLX, PEE | — |
| 7W4N | Deactive state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | m | PLX, PEE | 2 (best 0.91) |
| 7W4Q | Deactive state CI from Q1-NADH dataset, Subclass 6 | electron microscopy | m | PLX, PEE | 4 (best 0.90) |
| 8UD1 | High resolution in-situ structure of complex I in respiratory supercomplex (composite) | electron microscopy | 1J | PC1, 3PE | 5 (best 0.88) |
| 8UEO | In-situ complex I (Active-Apo) | electron microscopy | 1J | CDL, PC1 | 3 (best 0.90) |
| 8UER | In-situ complex I with Q10 (State-gamma) | electron microscopy | 1J | CDL | 4 (best 0.89) |
| 8UES | In-situ complex I, Deactive class01 | electron microscopy | 1J | PC1 | 1 (best 0.90) |
12 records more on the page itself.
Ligands
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 55 records
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 54 records
- CDL · Cardiolipin · in 34 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 13 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 6 records
Experiment against prediction
- 5GPN chain k against the predicted model O79882: TM-score 0.98, RMSD 0.72 Å
- 8UES chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.86 Å
- 8UEW chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.87 Å
- 8UEX chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.87 Å
- 8UD1 chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.89 Å
- 8UGJ chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.88 Å
- 8UER chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.79 Å
- 8UET chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.89 Å
- 8UGN chain 5J against the predicted model O79882: TM-score 0.97, RMSD 0.92 Å
- 8UEV chain 1J against the predicted model O79882: TM-score 0.97, RMSD 0.93 Å
Elsewhere
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