UniProt O76090
Bestrophin-1 (O76090)
Bestrophin-1 (UniProt O76090): 16 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 200 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O76090
- Protein
- Bestrophin-1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 200 · 10 records with a druggable one
Structures
17 records of O76090 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8D1I | hBest1 1uM Ca2+ (Ca2+-bound) closed state | electron microscopy | D, B, E, A, C | CA, MC3 | 20 (best 0.75) |
| 8D1I | HBEST1 1UM CA2+ (CA2+-bound) closed state | electron microscopy | D, B, E, A, C | CA, MC3 | — |
| 8D1J | hBest1 5mM Ca2+ (Ca2+-bound) closed state | electron microscopy | A, C, B, D, E | CA, MC3 | 20 (best 0.78) |
| 8D1J | HBEST1 5MM CA2+ (CA2+-bound) closed state | electron microscopy | A, C, B, D, E | CA, MC3 | — |
| 8D1K | hBest1 Ca2+-bound partially open neck state | electron microscopy | D, B, A, E, C | CA, MC3 | 20 (best 0.76) |
| 8D1K | HBEST1 CA2+-bound partially open neck state | electron microscopy | D, B, A, E, C | CA, MC3 | — |
| 8D1L | hBest1 Ca2+-bound partially open aperture state | electron microscopy | B, C, A, D, E | CA, MC3, CL | 20 (best 0.75) |
| 8D1L | HBEST1 CA2+-bound partially open aperture state | electron microscopy | B, C, A, D, E | CA, MC3, CL | — |
| 8D1M | hBest1 Ca2+-unbound closed state | electron microscopy | A, E, B, D, C | — | 20 (best 0.76) |
| 8D1M | HBEST1 CA2+-unbound closed state | electron microscopy | A, E, B, D, C | — | — |
| 8D1O | hBest1_345 Ca2+-bound open state | electron microscopy | E, A, B, C, D | MC3, CA | 20 (best 0.73) |
| 8D1O | HBEST1_345 CA2+-bound open state | electron microscopy | E, A, B, C, D | MC3, CA | — |
| 9CTQ | Best1 + GABA open state | electron microscopy | D, E, C, B, A | CA, ABU | 20 (best 0.72) |
| 9CTR | Best1 + GABA intermediate state 1 | electron microscopy | B, E, A, D, C | CA, ABU | 20 (best 0.76) |
| 9CTS | Best1 + GABA intermediate state 2 | electron microscopy | B, E, A, D, C | CA, ABU | 20 (best 0.76) |
| 9CTT | Best1 + GABA closed state | electron microscopy | D, B, E, A, C | CA | 20 (best 0.76) |
| O76090 | AlphaFold monomer V2.0 prediction for bestrophin-1 (O76090) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8D1K chain A against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain A against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain C against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain C against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain D against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain E against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain D against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain E against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain B against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
- 8D1K chain B against the predicted model O76090: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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