UniProt O75907
Diacylglycerol O-acyltransferase 1 (O75907)
Diacylglycerol O-acyltransferase 1 (UniProt O75907), EC 2.3.1.20, 2.3.1.76: 7 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O75907
- Protein
- Diacylglycerol O-acyltransferase 1
- EC
- 2.3.1.20, 2.3.1.76
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 38 · 4 records with a druggable one
Structures
8 records of O75907 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6VP0 | Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | electron microscopy | C, E | POV, P5S, 3VV, AV0 | 11 (best 0.85) |
| 6VP0 | Human diacylglycerol acyltransferase 1 in complex with oleoyl-CoA | electron microscopy | C, E | POV, 3VV, AV0 | — |
| 6VYI | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 | electron microscopy | A, B | 6OU | 9 (best 0.86) |
| 6VYI | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 | electron microscopy | A, B | 6OU | — |
| 6VZ1 | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate | electron microscopy | A, B | 6OU, 3VV | 7 (best 0.85) |
| 6VZ1 | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate | electron microscopy | A, B | 6OU, 3VV | — |
| 8ESM | Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | electron microscopy | A, B | WS0 | 11 (best 0.84) |
| O75907 | AlphaFold monomer V2.0 prediction for diacylglycerol O-acyltransferase 1 (O75907) | predicted | A | — | — |
Ligands
- 3VV · S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3, 5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2, 4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) · in 4 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 4 records
- AV0 · 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 1 record
- WS0 · {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid · in 1 record
Experiment against prediction
- 8ESM chain A against the predicted model O75907: TM-score 0.83, RMSD 3.25 Å
- 8ESM chain B against the predicted model O75907: TM-score 0.83, RMSD 3.25 Å
- 6VYI chain B against the predicted model O75907: TM-score 0.83, RMSD 3.31 Å
- 6VYI chain B against the predicted model O75907: TM-score 0.83, RMSD 3.31 Å
- 6VYI chain A against the predicted model O75907: TM-score 0.83, RMSD 3.31 Å
- 6VYI chain A against the predicted model O75907: TM-score 0.83, RMSD 3.31 Å
- 6VZ1 chain A against the predicted model O75907: TM-score 0.83, RMSD 3.32 Å
- 6VZ1 chain A against the predicted model O75907: TM-score 0.83, RMSD 3.32 Å
- 6VZ1 chain B against the predicted model O75907: TM-score 0.83, RMSD 3.32 Å
- 6VZ1 chain B against the predicted model O75907: TM-score 0.83, RMSD 3.32 Å
Elsewhere
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