UniProt O75844
CAAX prenyl protease 1 homolog (O75844)
CAAX prenyl protease 1 homolog (UniProt O75844), EC 3.4.24.84: 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O75844
- Protein
- CAAX prenyl protease 1 homolog
- EC
- 3.4.24.84
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 7 · 1 record with a druggable one
Structures
8 records of O75844 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YPT | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in… | x-ray diffraction | A, B, D, E | — | — |
| 2YPT | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in… | x-ray diffraction | A, B, D, E | — | — |
| 4AW6 | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) | x-ray diffraction | A, B, D, E | — | — |
| 4AW6 | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) | x-ray diffraction | A, B, D, E | — | — |
| 5SYT | Crystal structure of ZMPSTE24 | x-ray diffraction | A | SO4, PC1, CXE, ZN | — |
| 6BH8 | Crystal structure of ZMPSTE24 in complex with phosphoramidon | x-ray diffraction | A, B | ZN, RDF | 7 (best 0.71) |
| 6BH8 | Crystal structure of ZMPSTE24 in complex with phosphoramidon | x-ray diffraction | A, B | ZN | — |
| O75844 | AlphaFold monomer V2.0 prediction for caax prenyl protease 1 homolog (O75844) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6BH8 chain B against the predicted model O75844: TM-score 0.99, RMSD 0.68 Å
- 6BH8 chain A against the predicted model O75844: TM-score 0.99, RMSD 0.69 Å
- 6BH8 chain B against the predicted model O75844: TM-score 0.99, RMSD 0.68 Å
- 6BH8 chain A against the predicted model O75844: TM-score 0.99, RMSD 0.69 Å
- 2YPT chain E against the predicted model O75844: TM-score 0.99, RMSD 1.00 Å
- 2YPT chain E against the predicted model O75844: TM-score 0.99, RMSD 1.00 Å
- 4AW6 chain B against the predicted model O75844: TM-score 0.99, RMSD 1.00 Å
- 4AW6 chain B against the predicted model O75844: TM-score 0.99, RMSD 1.00 Å
- 2YPT chain D against the predicted model O75844: TM-score 0.99, RMSD 0.99 Å
- 2YPT chain D against the predicted model O75844: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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