UniProt O75582
Ribosomal protein S6 kinase alpha-5 (O75582)
Ribosomal protein S6 kinase alpha-5 (UniProt O75582), EC 2.7.11.1: 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O75582
- Protein
- Ribosomal protein S6 kinase alpha-5
- EC
- 2.7.11.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 30 · 5 records with a druggable one
Structures
17 records of O75582 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VZO | The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation… | x-ray diffraction | A | — | — |
| 1VZO | The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation… | x-ray diffraction | A | — | — |
| 3KN5 | Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP | x-ray diffraction | A, B | — | — |
| 3KN5 | Crystal structure of the C-terminal kinase domain of MSK1 in complex with AMP-pnp | x-ray diffraction | A, B | — | — |
| 3KN6 | Crystal structure of the C-terminal kinase domain of MSK1 | x-ray diffraction | A, B | — | — |
| 3KN6 | Crystal structure of the C-terminal kinase domain of MSK1 | x-ray diffraction | A, B | — | — |
| 7UP4 | Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O1K | 4 (best 0.65) |
| 7UP4 | Crystal structure of C-terminal domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O1K | — |
| 7UP5 | Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O1R, IOD | 7 (best 0.64) |
| 7UP5 | Crystal structure of C-terminal domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O1R, IOD | — |
| 7UP6 | Crystal structure of C-terminal domain of MSK1 in complex with in covalently bound literature RSK2… | x-ray diffraction | A | SUU, OXM | 2 (best 0.64) |
| 7UP6 | Crystal structure of C-terminal domain of MSK1 in complex with in covalently bound literature RSK2… | x-ray diffraction | A | SUU, OXM | — |
| 7UP7 | Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound with literature… | x-ray diffraction | A, B | 1LE | 9 (best 0.63) |
| 7UP7 | Crystal structure of C-terminal domain of MSK1 in complex with covalently bound with literature… | x-ray diffraction | A, B | 1LE | — |
| 7UP8 | Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O10 | 8 (best 0.67) |
| 7UP8 | Crystal structure of C-terminal domain of MSK1 in complex with covalently bound pyrrolopyrimidine… | x-ray diffraction | A, B | O10 | — |
| O75582 | AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-5 (O75582) | predicted | A | — | — |
Ligands
- 1LE · (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3, 4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide · in 2 records
- IOD · Iodide ion · in 2 records
- O10 · (5M)-5-(5-bromo-2-chloropyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine · in 2 records
- O1K · (5M)-5-(2,5-dichloropyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine · in 2 records
- O1R · (2M)-6-chloro-2-(5H-pyrrolo[3,2-d]pyrimidin-5-yl) pyridine-3-carbonitrile · in 2 records
- OXM · Oxamic acid · in 2 records
- SUU · (E)-3-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-cyanoacrylamide bound form · in 2 records
Experiment against prediction
- 7UP6 chain A against the predicted model O75582: TM-score 0.96, RMSD 1.39 Å
- 7UP6 chain A against the predicted model O75582: TM-score 0.96, RMSD 1.39 Å
- 7UP5 chain A against the predicted model O75582: TM-score 0.95, RMSD 1.75 Å
- 7UP5 chain A against the predicted model O75582: TM-score 0.95, RMSD 1.75 Å
- 7UP7 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.81 Å
- 7UP7 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.81 Å
- 7UP8 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.81 Å
- 7UP8 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.81 Å
- 7UP4 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.84 Å
- 7UP4 chain A against the predicted model O75582: TM-score 0.94, RMSD 1.84 Å
Elsewhere
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