UniProt O75475
PC4 and SFRS1-interacting protein (O75475)
PC4 and SFRS1-interacting protein (UniProt O75475), EC 2.1.1.43: 60 experimental structures and 1 predicted model on GenesisL1, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75475
- Protein
- PC4 and SFRS1-interacting protein
- EC
- 2.1.1.43
- Experimental structures
- 60
- Predicted models
- 1
- Pockets
- 70 · 15 records with a druggable one
Structures
61 records of O75475 in the MolNFT archive: 60 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z9E | Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75 | solution nmr | A | — | — |
| 1Z9E | Solution structure of the HIV-1 integrase-binding domain in LEDGF/P75 | solution nmr | A | — | — |
| 2B4J | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | x-ray diffraction | C, D | — | — |
| 2B4J | Structural basis for the recognition between HIV-1 integrase and LEDGF/P75 | x-ray diffraction | C, D | — | — |
| 2M16 | P75/LEDGF PWWP Domain | solution nmr | A | — | — |
| 2M16 | P75/LEDGF pwwp domain | solution nmr | A | — | — |
| 2MSR | Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160) | solution nmr | B | — | — |
| 2MSR | Solution structure of LEDGF/P75 ibd in complex with MLL1 peptide (140- 160) | solution nmr | B | — | — |
| 2MTN | Solution structure of MLL-IBD complex | solution nmr | A | — | — |
| 2MTN | Solution structure of mll-ibd complex | solution nmr | A | — | — |
| 2N3A | Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) | solution nmr | B | — | — |
| 2N3A | Solution structure of LEDGF/P75 ibd in complex with pogz peptide (1389-1404) | solution nmr | B | — | — |
| 3F9K | Two domain fragment of HIV-2 integrase in complex with LEDGF IBD | x-ray diffraction | C, G, K, O, S, W, a, e, i, m, q, u | — | — |
| 3F9K | Two domain fragment of HIV-2 integrase in complex with ledgf ibd | x-ray diffraction | C, G, K, O, S, W, a, e, i, m, q, u | — | — |
| 3HPG | Visna virus integrase (residues 1-219) in complex with LEDGF IBD: examples of open integrase… | x-ray diffraction | G, H, I, J, K, L | — | — |
| 3HPG | Visna virus integrase (residues 1-219) in complex with ledgf ibd: examples of open integrase… | x-ray diffraction | G, H, I, J, K, L | — | — |
| 3HPH | Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD | x-ray diffraction | E, F, G, H | — | — |
| 3HPH | Closed tetramer of visna virus integrase (residues 1-219) in complex with ledgf ibd | x-ray diffraction | E, F, G, H | — | — |
| 3U88 | Crystal structure of human menin in complex with MLL1 and LEDGF | x-ray diffraction | C, D | — | — |
| 3U88 | Crystal structure of human menin in complex with MLL1 and ledgf | x-ray diffraction | C, D | — | — |
| 3ZEH | Solution structure of the Hs. PSIP1 PWWP domain | solution nmr | A | — | — |
| 3ZEH | Solution structure of the hs. PSIP1 pwwp domain | solution nmr | A | — | — |
| 4FU6 | Crystal structure of the PSIP1 PWWP domain | x-ray diffraction | A | — | — |
| 4FU6 | Crystal structure of the PSIP1 pwwp domain | x-ray diffraction | A | — | — |
| 5N88 | Crystal structure of antibody bound to viral protein | x-ray diffraction | D, E | — | — |
| 5N88 | Crystal structure of antibody bound to viral protein | x-ray diffraction | D, E | — | — |
| 5OYM | HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor | x-ray diffraction | H, G, A, B, C, D, E, F | — | 8 (best 0.53) |
| 5OYM | HIV integrase binding domain of lens epithelium-derived growth factor | x-ray diffraction | H, G, A, B, C, D, E, F | — | — |
| 5YI9 | Solution structure of the LEDGF/p75 IBD - JPO2 (aa 56-91) complex | solution nmr | A | — | 1 (best 0.60) |
| 5YI9 | Solution structure of the LEDGF/P75 ibd - JPO2 (aa 56-91) complex | solution nmr | A | — | — |
| 6EMO | Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex | solution nmr | A | — | — |
| 6EMO | Solution structure of the LEDGF/P75 ibd - JPO2 (aa 1-32) complex | solution nmr | A | — | — |
| 6EMP | Solution structure of the LEDGF/p75 IBD - POGZ (aa 1370-1404) complex | solution nmr | A | — | — |
| 6EMP | Solution structure of the LEDGF/P75 ibd - pogz (aa 1370-1404) complex | solution nmr | A | — | — |
| 6EMQ | Solution structure of the LEDGF/p75 IBD - MLL1 (aa 111-160) complex | solution nmr | A | — | 1 (best 0.29) |
| 6EMQ | Solution structure of the LEDGF/P75 ibd - MLL1 (aa 111-160) complex | solution nmr | A | — | — |
| 6EMR | Solution structure of the LEDGF/p75 IBD - IWS1 (aa 446-548) complex | solution nmr | A | — | 1 (best 0.47) |
| 6EMR | Solution structure of the LEDGF/P75 ibd - IWS1 (aa 446-548) complex | solution nmr | A | — | — |
| 6S01 | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | electron microscopy | K | — | 2 (best 0.73) |
| 6S01 | Structure of ledgf pwwp domain bound H3K36 methylated nucleosome | electron microscopy | K | — | — |
| 6TRJ | LEDGF/p75 IBD dimer | x-ray diffraction | A | — | — |
| 6TRJ | LEDGF/P75 ibd dimer | x-ray diffraction | A | — | — |
| 6TVM | LEDGF/p75 dimer (residues 345-467) | solution nmr | A, B | — | 3 (best 0.63) |
| 6TVM | LEDGF/P75 dimer (residues 345-467) | solution nmr | A, B | — | — |
| 6ZV0 | TFIIS N-terminal domain (TND) from human LEDGF/p75 | solution nmr | A | — | — |
| 6ZV0 | Tfiis N-terminal domain (tnd) from human LEDGF/P75 | solution nmr | A | — | — |
| 7OUF | Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450 | electron microscopy | F, C | — | 13 (best 0.81) |
| 7OUF | Structure of the stlv INTASOME:B56 complex bound to the strand- transfer inhibitor XZ450 | electron microscopy | F, C | — | — |
| 7OUG | STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir | electron microscopy | F, C | — | 12 (best 0.81) |
| 7OUG | Stlv-1 INTASOME:B56 in complex with the strand-transfer inhibitor raltegravir | electron microscopy | F, C | — | — |
| 7PEL | CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory… | electron microscopy | C, F | — | 8 (best 0.79) |
| 7PEL | Cryoem structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory… | electron microscopy | C, F | — | — |
| 7Z1Z | MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | electron microscopy | R, Q | — | 2 (best 0.79) |
| 7Z1Z | Mvv strand transfer complex (stc) intasome in complex with LEDGF/P75 at 3.5 a resolution | electron microscopy | R, Q | — | 2 (best 0.79) |
| 8CBN | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | electron microscopy | K, L | — | 4 (best 0.75) |
| 8CBQ | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | electron microscopy | K | — | 1 (best 0.70) |
| 8PC5 | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex | electron microscopy | K | — | 1 (best 0.70) |
| 8PC6 | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | electron microscopy | K, L | — | 4 (best 0.77) |
| 8PEO | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex | electron microscopy | K | — | 2 (best 0.69) |
| 8PEP | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | electron microscopy | K, L | — | 5 (best 0.75) |
1 record more on the page itself.
Experiment against prediction
- 7OUG chain F against the predicted model Q13362: TM-score 0.97, RMSD 1.14 Å
- 7OUG chain F against the predicted model Q13362: TM-score 0.97, RMSD 1.14 Å
- 7OUG chain C against the predicted model Q13362: TM-score 0.97, RMSD 1.14 Å
- 7OUG chain C against the predicted model Q13362: TM-score 0.97, RMSD 1.14 Å
- 7PEL chain C against the predicted model Q13362: TM-score 0.97, RMSD 1.17 Å
- 7PEL chain C against the predicted model Q13362: TM-score 0.97, RMSD 1.17 Å
- 7PEL chain F against the predicted model Q13362: TM-score 0.97, RMSD 1.17 Å
- 7PEL chain F against the predicted model Q13362: TM-score 0.97, RMSD 1.17 Å
- 2B4J chain C against the predicted model O75475: TM-score 0.97, RMSD 0.84 Å
- 2B4J chain C against the predicted model O75475: TM-score 0.97, RMSD 0.84 Å
Elsewhere
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