MolNFT v1 · #165444 · protein

LEDGF/P75 dimer (residues 345-467)

6TVM · PC4 and SFRS1-interacting protein: “LEDGF/P75 dimer (residues 345-467)”. Solution nmr, 3 pockets (best druggability 0.63). MolNFT v1 #165444 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TVM
Type: protein
Length: 256 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PC4 and SFRS1-interacting protein
UniProt: O75475
Pockets: 3 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 58% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	PC4 and SFRS1-interacting protein	protein	128	58% helix, 0% strand	O75475

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	618	0.63	0.74	59	empty
2	79	0.34	0.75	16	empty
3	68	0.32	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 3255 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6TVM · LEDGF/p75 dimer (residues 345-467) · the same entry in another collection · chain A against A, TM-score 1.00
O75475 · AlphaFold monomer V2.0 prediction for PC4 and SFRS1-interacting protein (O75475) · a predicted model of the same protein · chain A against A, TM-score 0.47

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75475
Elsewhere: RCSB PDB 6TVM · PDBe 6TVM · UniProt O75475

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