UniProt O75311
Glycine receptor subunit alpha-3 (O75311)
Glycine receptor subunit alpha-3 (UniProt O75311): 15 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 200 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75311
- Protein
- Glycine receptor subunit alpha-3
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 200 · 10 records with a druggable one
Structures
16 records of O75311 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CFB | Crystal structure of human glycine receptor alpha-3 bound to strychnine | x-ray diffraction | A, B, C, D, E | — | — |
| 5TIN | Crystal structure of human glycine receptor alpha-3 mutant N38Q bound to am-3607 | x-ray diffraction | A, B, C, D, E | 7C6, ZN | — |
| 5TIO | Crystal structure of human glycine receptor alpha-3 bound to am-3607 | x-ray diffraction | C, A, B, D, E | 7C6, ZN, NAG | — |
| 5VDH | Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin | x-ray diffraction | A, B, C, D, E | 7C6, GLY, IVM, ZN, NAG | 20 (best 0.79) |
| 5VDH | Crystal structure of human glycine receptor alpha-3 bound to am-3607, glycine, and ivermectin | x-ray diffraction | A, B, C, D, E | 7C6, IVM, ZN, NAG | — |
| 5VDI | Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and… | x-ray diffraction | A, B, C, D, E | 7C6, GLY, IVM, ZN | 20 (best 0.81) |
| 5VDI | Crystal structure of human glycine receptor alpha-3 mutant N38Q bound to am-3607, glycine, and… | x-ray diffraction | A, B, C, D, E | 7C6, IVM, ZN | — |
| 9BU2 | Homomeric alpha3 glycine receptor in the presence of 1 mM glycine at pH 6.4 in a desensitized state | electron microscopy | A, B, C, D, E | NAG, GLY, PIO, PX4 | 20 (best 0.82) |
| 9BU3 | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine in a desensitized state | electron microscopy | A, B, C, D, E | NAG, GLY, PIO, PX4 | 19 (best 0.81) |
| 9BWB | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in a desensitized… | electron microscopy | A, B, C, D, E | NAG, GLY, PIO, PX4 | 20 (best 0.82) |
| 9BWC | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an apo state | electron microscopy | A, B, C, D, E | NAG, PX4, PIO, GLY | 20 (best 0.82) |
| 9BWE | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an intermediate… | electron microscopy | A, B, C, D, E | NAG, PIO, PX4, GLY | 20 (best 0.83) |
| 9BWG | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in a… | electron microscopy | A, B, C, D, E | NAG, GLY, ZN, PIO, PX4 | 20 (best 0.80) |
| 9BWJ | Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in an apo state | electron microscopy | A, B, C, D, E | NAG, ZN, PX4 | 20 (best 0.78) |
| 9BZP | Homomeric alpha3 glycine receptor in the presence of 0.1 millimolar glycine and 1 micromolar zinc… | electron microscopy | A, B, C, D, E | NAG, GLY, ZN, PIO, PX4 | 20 (best 0.77) |
| O75311 | AlphaFold monomer V2.0 prediction for glycine receptor subunit alpha-3 (O75311) | predicted | A | — | 1 (best 0.37) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 11 records
- GLY · Glycine · in 9 records
- ZN · Zinc ion · in 9 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 8 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 7 records
- 7C6 · (3s,3as,9bs)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3A,5,9B-hexahydro-4H-pyrrolo[3,4-C][1, 6]naphthyridin-4-one · in 6 records
- IVM · (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar, 20BS)-6'-[(2S)-butan-2-yl]-20,20B-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17A, 20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside · in 4 records
Experiment against prediction
- 9BWG chain C against the predicted model O75311: TM-score 0.99, RMSD 0.68 Å
- 9BWG chain E against the predicted model O75311: TM-score 0.99, RMSD 0.68 Å
- 9BWG chain A against the predicted model O75311: TM-score 0.99, RMSD 0.68 Å
- 9BWG chain D against the predicted model O75311: TM-score 0.99, RMSD 0.68 Å
- 9BWG chain B against the predicted model O75311: TM-score 0.99, RMSD 0.68 Å
- 5VDI chain E against the predicted model O75311: TM-score 0.99, RMSD 0.71 Å
- 5VDI chain A against the predicted model O75311: TM-score 0.99, RMSD 0.71 Å
- 5VDI chain B against the predicted model O75311: TM-score 0.99, RMSD 0.73 Å
- 5VDI chain C against the predicted model O75311: TM-score 0.99, RMSD 0.73 Å
- 9BWB chain B against the predicted model O75311: TM-score 0.99, RMSD 0.75 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.