UniProt O74024
Glutamate dehydrogenase (O74024)
Glutamate dehydrogenase (UniProt O74024), EC 1.4.1.2, 1.4.1.3: 40 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O74024
- Protein
- Glutamate dehydrogenase
- EC
- 1.4.1.2, 1.4.1.3
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 72 · 34 records with a druggable one
Structures
41 records of O74024 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EUZ | Glutamate dehydrogenase from thermococcus profundus in the unligated state | x-ray diffraction | A, B, C, D, E, F | SO4 | 17 (best 0.89) |
| 1EUZ | Glutamate dehydrogenase from thermococcus profundus in the unligated state | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6JN9 | Cryo-EM structure of glutamate dehydrogenase from Thermococcus profundus | electron microscopy | A | — | 1 (best 0.69) |
| 6JN9 | Cryo-EM structure of glutamate dehydrogenase from thermococcus profundus | electron microscopy | A | — | — |
| 6JNA | Cryo-EM structure of glutamate dehydrogenase from Thermococcus profundus | electron microscopy | A | — | 1 (best 0.72) |
| 6JNA | Cryo-EM structure of glutamate dehydrogenase from thermococcus profundus | electron microscopy | A | — | — |
| 6JNC | Cryo-EM structure of glutamate dehydrogenase from Thermococcus profundus | electron microscopy | A | — | — |
| 6JNC | Cryo-EM structure of glutamate dehydrogenase from thermococcus profundus | electron microscopy | A | — | — |
| 6JND | Cryo-EM structure of glutamate dehydrogenase from Thermococcus profundus | electron microscopy | A | — | 3 (best 0.75) |
| 6JND | Cryo-EM structure of glutamate dehydrogenase from thermococcus profundus | electron microscopy | A | — | — |
| 8HHO | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | electron microscopy | A | NAP | 1 (best 0.73) |
| 8HIQ | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | electron microscopy | A | NAP | 1 (best 0.69) |
| 8HIZ | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | electron microscopy | A | NAP | 1 (best 0.73) |
| 8HJ3 | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | electron microscopy | A | NAP | 1 (best 0.75) |
| 8HJ9 | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | electron microscopy | A | NAP | 1 (best 0.69) |
| 8XCO | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH in the… | electron microscopy | A | NDP | 1 (best 0.73) |
| 8XCP | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 2 (best 0.74) |
| 8XCQ | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.74) |
| 8XCR | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus in complex with NADP and… | electron microscopy | A | NAP, GGL | 2 (best 0.74) |
| 8XCS | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus in complex with NADPH, AKG… | electron microscopy | A | NDP, AKG, NH4 | 2 (best 0.74) |
| 8XCT | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH in the… | electron microscopy | A | NDP | 1 (best 0.74) |
| 8XCU | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG… | electron microscopy | A | NDP, AKG, GGL | 1 (best 0.74) |
| 8XCV | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP in the… | electron microscopy | A | NAP | 2 (best 0.67) |
| 8XCW | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and… | electron microscopy | A | NDP, AKG | 2 (best 0.73) |
| 8XCX | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.73) |
| 8XCY | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.72) |
| 8XCZ | Cryo-EM structure of glutamate dehydrogenase from thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.74) |
| 8XD0 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and… | electron microscopy | A | NDP, AKG | 2 (best 0.75) |
| 8XD1 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP in the… | electron microscopy | A | NAP | 1 (best 0.74) |
| 8XD2 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.75) |
| 8XD3 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.74) |
| 8XD4 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus incorporating NADP and GLU… | electron microscopy | A | NAP, GGL | 1 (best 0.74) |
| 8XD5 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus in complex with NADP and… | electron microscopy | A | NAP, GGL | 1 (best 0.75) |
| 8XD6 | Cryo-EM structure of Glutamate dehydrogenase from Thermococcus profundus in complex with NADPH, AKG… | electron microscopy | A | NDP, AKG, NH4 | 1 (best 0.75) |
| 8ZMU | Glutamate dehydrogenase (W89F-mutant) from thermococcus profundus in the unliganded state | x-ray diffraction | A, B, C, D, E, F | SO4, NA | 15 (best 0.89) |
| 8ZNB | Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating… | electron microscopy | A | NDP | 1 (best 0.72) |
| 8ZNC | Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating… | electron microscopy | A | NDP, AKG, NH4 | 1 (best 0.74) |
| 8ZND | Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating… | electron microscopy | A | NDP | 1 (best 0.73) |
| 8ZNE | Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex… | electron microscopy | A | NAP, GLU | 1 (best 0.74) |
| 8ZNG | Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex… | electron microscopy | A | NDP, AKG | 1 (best 0.74) |
| O74024 | AlphaFold monomer V2.0 prediction for glutamate dehydrogenase (O74024) | predicted | A | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 18 records
- GGL · Gamma-L-glutamic acid · in 11 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 11 records
- AKG · 2-oxoglutaric acid · in 7 records
- NH4 · Ammonium ion · in 3 records
- SO4 · Sulfate ion · in 2 records
- GLU · Glutamic acid · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 8XCW chain A against the predicted model O74024: TM-score 1.00, RMSD 0.39 Å
- 8XCX chain A against the predicted model O74024: TM-score 1.00, RMSD 0.39 Å
- 8XCY chain A against the predicted model O74024: TM-score 1.00, RMSD 0.40 Å
- 8XCV chain A against the predicted model O74024: TM-score 1.00, RMSD 0.40 Å
- 8ZNC chain A against the predicted model O74024: TM-score 1.00, RMSD 0.41 Å
- 8XCP chain A against the predicted model O74024: TM-score 1.00, RMSD 0.41 Å
- 8XCZ chain A against the predicted model O74024: TM-score 1.00, RMSD 0.43 Å
- 8XCT chain A against the predicted model O74024: TM-score 1.00, RMSD 0.47 Å
- 8XCU chain A against the predicted model O74024: TM-score 1.00, RMSD 0.47 Å
- 1EUZ chain D against the predicted model O74024: TM-score 1.00, RMSD 0.56 Å
Elsewhere
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