UniProt O67077
ATP-dependent zinc metalloprotease FtsH (O67077)
ATP-dependent zinc metalloprotease FtsH (UniProt O67077), EC 3.4.24.-: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O67077
- Protein
- ATP-dependent zinc metalloprotease FtsH
- EC
- 3.4.24.-
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 32 · 2 records with a druggable one
Structures
11 records of O67077 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DI4 | Crystal structure of the FtsH protease domain | x-ray diffraction | A, B | — | — |
| 2DI4 | Crystal structure of the ftsh protease domain | x-ray diffraction | A, B | — | — |
| 4WW0 | Truncated FtsH from A. aeolicus | x-ray diffraction | A, B, C | — | — |
| 4WW0 | Truncated ftsh from a. aeolicus | x-ray diffraction | A, B, C | — | — |
| 4Z8X | Truncated FtsH from A. aeolicus | x-ray diffraction | A, B, C | — | — |
| 4Z8X | Truncated ftsh from a. aeolicus | x-ray diffraction | A, B, C | — | — |
| 6GCN | Truncated FtsH from A. aeolicus in R32 | x-ray diffraction | A, B, C, D | ADP, ZN | 20 (best 0.77) |
| 6GCN | Truncated ftsh from a. aeolicus in R32 | x-ray diffraction | A, B, C, D | ADP, ZN | — |
| 6GCO | Truncated FtsH from A. aeolicus in P312 | x-ray diffraction | A, B | ADP, ZN | 12 (best 0.74) |
| 6GCO | Truncated ftsh from a. aeolicus in P312 | x-ray diffraction | A, B | ADP, ZN | — |
| O67077 | AlphaFold monomer V2.0 prediction for ATP-dependent zinc metalloprotease ftsh (O67077) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2DI4 chain B against the predicted model O67077: TM-score 0.97, RMSD 0.90 Å
- 2DI4 chain B against the predicted model O67077: TM-score 0.97, RMSD 0.90 Å
- 2DI4 chain A against the predicted model O67077: TM-score 0.96, RMSD 1.17 Å
- 2DI4 chain A against the predicted model O67077: TM-score 0.96, RMSD 1.17 Å
- 4WW0 chain A against the predicted model O67077: TM-score 0.62, RMSD 3.32 Å
- 4WW0 chain A against the predicted model O67077: TM-score 0.62, RMSD 3.32 Å
- 4Z8X chain B against the predicted model O67077: TM-score 0.62, RMSD 3.99 Å
- 4Z8X chain B against the predicted model O67077: TM-score 0.62, RMSD 3.99 Å
- 4Z8X chain C against the predicted model O67077: TM-score 0.62, RMSD 3.80 Å
- 4Z8X chain C against the predicted model O67077: TM-score 0.62, RMSD 3.80 Å
Elsewhere
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