MolNFT v1 · #149862 · protein
Truncated ftsh from a. aeolicus in P312
6GCO · ATP-dependent zinc metalloprotease ftsh: “Truncated ftsh from a. aeolicus in P312”. X-ray diffraction, 2 ligands (ADP, ZN), 12 pockets (best druggability 0.74). MolNFT v1 #149862 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6GCO
- Type
- protein
- Length
- 804 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent zinc metalloprotease ftsh
- EC
- 3.4.24.-
- UniProt
- O67077
- Ligands
- ADP, ZN
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 409 | 57% helix, 8% strand | O67077 |
| B | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 395 | 60% helix, 7% strand | O67077 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.74 | 0.81 | 71 | empty |
| 2 | 294 | 0.74 | 0.87 | 41 | empty |
| 3 | 551 | 0.73 | 0.81 | 85 | ADP |
| 4 | 466 | 0.73 | 0.82 | 62 | ADP |
| 5 | 205 | 0.64 | 0.83 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 942 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67077
- Elsewhere: RCSB PDB 6GCO · PDBe 6GCO · UniProt O67077
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