MolNFT v1 · #112036 · protein

Truncated ftsh from a. aeolicus

4Z8X · ATP-dependent zinc metalloprotease ftsh: “Truncated ftsh from a. aeolicus”. X-ray diffraction, 3 ligands (ADP, ZN, SO4), 16 pockets (best druggability 0.72). MolNFT v1 #112036 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4Z8X
Type: protein
Length: 1,273 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent zinc metalloprotease ftsh
EC: 3.4.24.-
UniProt: O67077
Ligands: ADP, ZN, SO4
Pockets: 16 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-)	protein	425	52% helix, 9% strand	O67077
C	ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-)	protein	423	53% helix, 8% strand	O67077

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, C
ZN · Zinc ion · metal · 3 copies · chains A, B, C
SO4 · Sulfate ion · ion · 3 copies · chains A, C, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1054	0.72	0.76	105	ADP
2	846	0.70	0.76	103	ZN, ADP
3	115	0.69	0.91	21	empty
4	736	0.69	0.76	81	empty
5	67	0.69	0.94	17	empty

Interfaces

2 interfaces between chains.

A–B · 1607 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 1547 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

4Z8X · Truncated FtsH from A. aeolicus · the same entry in another collection · chain A against A, TM-score 1.00
O67077 · AlphaFold monomer V2.0 prediction for ATP-dependent zinc metalloprotease ftsh (O67077) · a predicted model of the same protein · chain B against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O67077
Elsewhere: RCSB PDB 4Z8X · PDBe 4Z8X · UniProt O67077

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.