UniProt O64411
Polyamine oxidase (O64411)
Polyamine oxidase (UniProt O64411), EC 1.5.3.-, 1.5.3.11: 18 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 278 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O64411
- Protein
- Polyamine oxidase
- EC
- 1.5.3.-, 1.5.3.11, 1.5.3.14, 1.5.3.15
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 278 · 19 records with a druggable one
Structures
19 records of O64411 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B37 | A 30 ångström U-shaped catalytic tunnel in the crystal structure of polyamine oxidase | x-ray diffraction | A, B, C | NAG, FAD | 16 (best 0.84) |
| 1B37 | A 30 ångström U-shaped catalytic tunnel in the crystal structure of polyamine oxidase | x-ray diffraction | A, B, C | NAG, FAD | 16 (best 0.84) |
| 1H81 | Structure of polyamine oxidase in the reduced state | x-ray diffraction | A, B, C | NAG, FAD | 16 (best 0.85) |
| 1H81 | Structure of polyamine oxidase in the reduced state | x-ray diffraction | A, B, C | NAG, FAD | 16 (best 0.85) |
| 1H82 | Structure of polyamine oxidase in complex with guazatine | x-ray diffraction | A, B, C | NAG, FAD, GZZ | 17 (best 0.86) |
| 1H82 | Structure of polyamine oxidase in complex with guazatine | x-ray diffraction | A, B, C | NAG, FAD, GZZ | 17 (best 0.86) |
| 1H83 | Structure of polyamine oxidase in complex with 1,8-diaminooctane | x-ray diffraction | A, B, C | NAG, FAD, DIA | 15 (best 0.84) |
| 1H83 | Structure of polyamine oxidase in complex with 1,8-diaminooctane | x-ray diffraction | A, B, C | NAG, FAD, DIA | 15 (best 0.84) |
| 1H84 | COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ethylN11((cycloheptyl)methyl)4,8diazaundecane at pH… | x-ray diffraction | A, B, C | NAG, FAD, NBA | 18 (best 0.84) |
| 1H84 | Covalent adduct between polyamine oxidase and N1ETHYLN11((CYCLOHEPTYL)METHYL)4,8DIAZAUNDECANE at pH… | x-ray diffraction | A, B, C | NAG, FAD, NBA | 18 (best 0.84) |
| 1H86 | COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ethylN11((cycloheptyl)methyl)4,8diazaundecane at pH… | x-ray diffraction | A, B, C | NAG, FAD, NBA | 18 (best 0.86) |
| 1H86 | Covalent adduct between polyamine oxidase and N1ETHYLN11((CYCLOHEPTYL)METHYL)4,8DIAZAUNDECANE at pH… | x-ray diffraction | A, B, C | NAG, FAD, NBA | 18 (best 0.86) |
| 3KPF | X-ray structure of the mutant Lys300Met of polyamine oxidase from Zea mays | x-ray diffraction | A, B | NAG, FAD, CL, SO4 | 14 (best 0.86) |
| 3KPF | X-ray structure of the mutant LYS300MET of polyamine oxidase from zea mays | x-ray diffraction | A, B | NAG, FAD, CL, SO4 | 14 (best 0.86) |
| 3KU9 | X-ray structure of the mutant lys300met of polyamine oxidase from zea mays in complex with spermine | x-ray diffraction | A, B | NAG, FAD, SPM, CL, SO4 | 12 (best 0.86) |
| 3KU9 | X-ray structure of the mutant LYS300MET of polyamine oxidase from zea mays in complex with spermine | x-ray diffraction | A, B | NAG, FAD, SPM, CL, SO4 | 12 (best 0.86) |
| 3L1R | X-ray structure of the mutant lys300met of polyamine oxidase from zea mays in complex with… | x-ray diffraction | A, B | NAG, FAD, SPD, SO4, CL | 11 (best 0.88) |
| 3L1R | X-ray structure of the mutant LYS300MET of polyamine oxidase from zea mays in complex with… | x-ray diffraction | A, B | NAG, FAD, SPD, SO4, CL | 11 (best 0.88) |
| O64411 | AlphaFold monomer V2.0 prediction for polyamine oxidase 1 (O64411) | predicted | A | — | 4 (best 0.83) |
Ligands
- FAD · Flavin-adenine dinucleotide · in 18 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 18 records
- CL · Chloride ion · in 6 records
- SO4 · Sulfate ion · in 6 records
- NBA · 3-[(3-{[3-(methylamino)propyl]amino}propyl)amino]propane-1,1-diol · in 4 records
- DIA · Octane 1,8-diamine · in 2 records
- GZZ · N-{8-[(8-{[(E)-amino(imino)methyl]amino}octyl)amino]octyl}guanidine · in 2 records
- SPD · Spermidine · in 2 records
- SPM · Spermine · in 2 records
Experiment against prediction
- 1H84 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.27 Å
- 1H84 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.27 Å
- 1B37 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.27 Å
- 1B37 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.27 Å
- 1H83 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
- 1H83 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
- 1H82 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
- 1H82 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
- 1H86 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
- 1H86 chain A against the predicted model O64411: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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