UniProt O60930
Ribonuclease H1 (O60930)
Ribonuclease H1 (UniProt O60930), EC 3.1.26.4: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60930
- Protein
- Ribonuclease H1
- EC
- 3.1.26.4
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 2 records with a druggable one
Structures
11 records of O60930 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QK9 | Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid | x-ray diffraction | A | — | — |
| 2QK9 | Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid | x-ray diffraction | A | — | — |
| 2QKB | Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid | x-ray diffraction | A, B | — | — |
| 2QKB | Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid | x-ray diffraction | A, B | — | — |
| 2QKK | Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid | x-ray diffraction | A, B, E, F, I, J, M, N, R, S, W | — | — |
| 2QKK | Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid | x-ray diffraction | A, B, E, F, I, J, M, N, R, S, W | — | — |
| 3BSU | Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA | x-ray diffraction | A, B, C, F, G, H | — | — |
| 3BSU | Hybrid-binding domain of human RNase H1 in complex with 12- mer RNA/DNA | x-ray diffraction | A, B, C, F, G, H | — | — |
| 6VRD | Crystal structure of RNase H/RNA/PS-aso complex at an atomic level | x-ray diffraction | A | SO4 | — |
| 8SWB | RNase H complex with streopure ASO and RNA | x-ray diffraction | A | PO4 | 1 (best 0.59) |
| O60930 | AlphaFold monomer V2.0 prediction for ribonuclease H1 (O60930) | predicted | A | — | 3 (best 0.70) |
Ligands
Experiment against prediction
- 2QKB chain A against the predicted model O60930: TM-score 0.99, RMSD 0.38 Å
- 2QKB chain A against the predicted model O60930: TM-score 0.99, RMSD 0.38 Å
- 2QKK chain R against the predicted model O60930: TM-score 0.99, RMSD 0.51 Å
- 2QKK chain R against the predicted model O60930: TM-score 0.99, RMSD 0.51 Å
- 2QK9 chain A against the predicted model O60930: TM-score 0.99, RMSD 0.67 Å
- 2QK9 chain A against the predicted model O60930: TM-score 0.99, RMSD 0.67 Å
- 2QKK chain M against the predicted model O60930: TM-score 0.99, RMSD 0.56 Å
- 2QKK chain M against the predicted model O60930: TM-score 0.99, RMSD 0.56 Å
- 2QKK chain E against the predicted model O60930: TM-score 0.98, RMSD 0.67 Å
- 2QKK chain E against the predicted model O60930: TM-score 0.98, RMSD 0.67 Å
Elsewhere
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