UniProt O60313
Dynamin-like 120 kDa protein, mitochondrial (O60313)
Dynamin-like 120 kDa protein, mitochondrial (UniProt O60313), EC 3.6.5.5: 7 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 123 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60313
- Protein
- Dynamin-like 120 kDa protein, mitochondrial
- EC
- 3.6.5.5
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 123 · 7 records with a druggable one
Structures
8 records of O60313 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6JTG | Structural insights into G domain dimerization and pathogenic mutations of OPA1 | x-ray diffraction | A | GDP, MG, BEF, K | — |
| 8CT1 | CryoEM structure of human S-OPA1 assembled on lipid membrane in membrane-adjacent state | electron microscopy | A, a, B, b, C, c, D, d, E, e, F, f, G, g, H, h, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z | — | 20 (best 0.85) |
| 8CT9 | CryoEM structure of human S-OPA1 assembled on lipid membrane in membrane-distal state | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h | CDL | 20 (best 0.85) |
| 8EEW | CryoEM of the soluble OPA1 dimer from the GDP-AlFx bound helical assembly on a lipid membrane | electron microscopy | A, B | GDP, ALF, MG, K | 18 (best 0.85) |
| 8EF7 | CryoEM of the soluble OPA1 dimer from the apo helical assembly on a lipid membrane | electron microscopy | A, B | — | 17 (best 0.86) |
| 8EFR | CryoEM of the soluble OPA1 interfaces with GDP-AlFx bound from the helical assembly on a lipid… | electron microscopy | A, B, C, K, D, L, E, M, F, N, G, O, H, P, I, Q, J, R | GDP, ALF, MG, K | 20 (best 0.87) |
| 8EFT | CryoEM of the soluble OPA1 interfaces from the apo helical assembly on a lipid membrane | electron microscopy | A, B, C, K, D, L, E, M, F, N, G, O, H, P, I, Q, J, R | — | 20 (best 0.86) |
| O60313 | AlphaFold monomer V2.0 prediction for dynamin-like 120 kda protein, mitochondrial (O60313) | predicted | A | — | 8 (best 0.63) |
Ligands
Experiment against prediction
- 8CT1 chain K against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain W against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain d against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain C against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain R against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain V against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain h against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain O against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain U against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
- 8CT1 chain f against the predicted model O60313: TM-score 0.97, RMSD 1.63 Å
Elsewhere
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