UniProt O59952
Lipase (O59952)
Lipase (UniProt O59952), EC 3.1.1.3: 56 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O59952
- Protein
- Lipase
- EC
- 3.1.1.3
- Experimental structures
- 56
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 26 · 3 records with a druggable one
Structures
57 records of O59952 in the MolNFT archive: 56 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DT3 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B | — | — |
| 1DT3 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B | — | — |
| 1DT5 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1DT5 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1DTE | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B | — | — |
| 1DTE | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B | — | — |
| 1DU4 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase other… | x-ray diffraction | A, B, C, D | — | — |
| 1DU4 | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase other… | x-ray diffraction | A, B, C, D | — | — |
| 1EIN | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B, C | — | — |
| 1EIN | The structural origins of interfacial activation in thermomyces (humicola) lanuginosa lipase | x-ray diffraction | A, B, C | — | — |
| 1GT6 | S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid | x-ray diffraction | A, B | — | — |
| 1GT6 | S146A mutant of thermomyces (humicola) lanuginosa lipase complex with oleic acid | x-ray diffraction | A, B | — | — |
| 1TIB | Conformational lability of lipases observed in the absence of an oil-water interface… | x-ray diffraction | A | — | — |
| 1TIB | Conformational lability of lipases observed in the absence of an oil-water interface… | x-ray diffraction | A | — | — |
| 4DYH | Crystal structure of glycosylated Lipase from Humicola lanuginosa at 2 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 4DYH | Crystal structure of glycosylated lipase from humicola lanuginosa at 2 ångström resolution | x-ray diffraction | A, B | — | — |
| 4EA6 | Crystal structure of Fungal lipase from Thermomyces(Humicola) lanuginosa at 2.30 Angstrom… | x-ray diffraction | A, B | — | — |
| 4EA6 | Crystal structure of fungal lipase from THERMOMYCES(HUMICOLA) lanuginosa at 2.30 ångström… | x-ray diffraction | A, B | — | — |
| 4FLF | Structure of three phase partition treated lipase from Thermomyces lanuginosa at 2.15A resolution. | x-ray diffraction | A, B | — | — |
| 4FLF | Structure of three phase partition treated lipase from thermomyces lanuginosa at 2.15A resolution. | x-ray diffraction | A, B | — | — |
| 4GBG | Crystal structure of Ethyl acetoacetate treated lipase from Thermomyces lanuginosa at 2.9 A… | x-ray diffraction | A, B | — | — |
| 4GBG | Crystal structure of ethyl acetoacetate treated lipase from thermomyces lanuginosa at 2.9 a… | x-ray diffraction | A, B | — | — |
| 4GHW | Crystal structure of the complex of Fungal lipase from Thermomyces lanuginosa with decanoic acid at… | x-ray diffraction | A, B | — | — |
| 4GHW | Crystal structure of the complex of fungal lipase from thermomyces lanuginosa with decanoic acid at… | x-ray diffraction | A, B | — | — |
| 4GI1 | Structure of the complex of three phase partition treated lipase from Thermomyces lanuginosa with… | x-ray diffraction | A, B | — | — |
| 4GI1 | Structure of the complex of three phase partition treated lipase from thermomyces lanuginosa with… | x-ray diffraction | A, B | — | — |
| 4GLB | Structure of p-nitrobenzaldehyde inhibited lipase from Thermomyces lanuginosa at 2.69 A resolution | x-ray diffraction | A, B | — | — |
| 4GLB | Structure of P-nitrobenzaldehyde inhibited lipase from thermomyces lanuginosa at 2.69 a resolution | x-ray diffraction | A, B | — | — |
| 4GWL | Structure of three phase partition treated lipase from Thermomyces lanuginosa at 2.55A resolution | x-ray diffraction | A, B | — | — |
| 4GWL | Structure of three phase partition treated lipase from thermomyces lanuginosa at 2.55A resolution | x-ray diffraction | A, B | — | — |
| 4KJX | Crystal Structure of the complex of three phase partition treated lipase from Thermomyces… | x-ray diffraction | A, B | — | — |
| 4KJX | Crystal structure of the complex of three phase partition treated lipase from thermomyces… | x-ray diffraction | A, B | — | — |
| 4N8S | Crystal Structure of the ternary complex of lipase from Thermomyces lanuginosa with… | x-ray diffraction | A, B | — | — |
| 4N8S | Crystal structure of the ternary complex of lipase from thermomyces lanuginosa with… | x-ray diffraction | A, B | — | — |
| 4S0X | Structure of three phase partition - treated lipase from Thermomyces lanuginosa in complex with… | x-ray diffraction | A, B | — | — |
| 4S0X | Structure of three phase partition - treated lipase from thermomyces lanuginosa in complex with… | x-ray diffraction | A, B | — | — |
| 4ZGB | Structure of untreated lipase from Thermomyces lanuginosa at 2.3 A resolution | x-ray diffraction | A, B | — | — |
| 4ZGB | Structure of untreated lipase from thermomyces lanuginosa at 2.3 a resolution | x-ray diffraction | A, B | — | — |
| 5AP9 | Controlled lid-opening in Thermomyces lanuginosus lipase - a switch for activity and binding | x-ray diffraction | A, B | — | — |
| 5AP9 | Controlled lid-opening in thermomyces lanuginosus lipase - a switch for activity and binding | x-ray diffraction | A, B | — | — |
| 6HW1 | Room temperature structure of lipase from T. lanuginosa at 2.5 a resolution in chipx microfluidic… | x-ray diffraction | A, B | NAG, PO4, MG | — |
| 6HW1 | Room temperature structure of lipase from T. lanuginosa at 2.5 a resolution in chipx microfluidic… | x-ray diffraction | A, B | NAG, PO4, MG | — |
| 6O9F | The structure of Thermomyces Lanuginosa lipase in complex with 1,3 diacylglycerol in a monoclinic… | x-ray diffraction | A, B, C, E, D, F | OCA, CA, NAG, LTV, PO4 | — |
| 6OR3 | Structure of an Acyl Intermediate of Thermomyces Lanuginosa Lipase With Palmitic Acid in an… | x-ray diffraction | A | CA, PLM, NAG | 1 (best 0.49) |
| 6OR3 | Structure of an acyl intermediate of thermomyces lanuginosa lipase with palmitic acid in an… | x-ray diffraction | A | CA, PLM, NAG | — |
| 6OSZ | High Resolution Structure of the Monoclinic Form of Thermomyces Lanuginosa Lipase Complexed with… | x-ray diffraction | A, B, C, E, D, F | OCA, NAG, LTV, PO4, CA | — |
| 6XOK | X-ray structure of the rhombohedral form of the lipase from Thermomyces lanuginosa at 1.3 A… | x-ray diffraction | A | NAG, PO4, LTV | 1 (best 0.55) |
| 6XOK | X-ray structure of the rhombohedral form of the lipase from thermomyces lanuginosa at 1.3 a… | x-ray diffraction | A | NAG, PO4, LTV | — |
| 6XRV | X-ray structure of the monoclinic crystal form at 1.43 A resolution of lipase from Thermomyces… | x-ray diffraction | A, B, C, E, D, F | OCA, NAG, LTV, PO4, CA | — |
| 6XRV | X-ray structure of the monoclinic crystal form at 1.43 a resolution of lipase from thermomyces… | x-ray diffraction | A, B, C, E, D, F | OCA, NAG, LTV, PO4, CA | — |
| 6XS3 | X-ray structure of the monoclinic crystal form at 2.48 A resolution of lipase from Thermomyces… | x-ray diffraction | A, B, C, E, D, F | OCA, CA, NAG, LTV, PO4 | 12 (best 0.81) |
| 6XS3 | X-ray structure of the monoclinic crystal form at 2.48 a resolution of lipase from thermomyces… | x-ray diffraction | A, B, C, E, D, F | OCA, CA, NAG, LTV, PO4 | — |
| 7APN | Structure of Lipase TL from bulk agarose grown crystal | x-ray diffraction | A, B | NAG, PO4, MG | 6 (best 0.60) |
| 7APN | Structure of lipase tl from bulk agarose grown crystal | x-ray diffraction | A, B | NAG, PO4, MG | — |
| 7APP | Structure of Lipase TL from capillary grown crystal in the presence of agarose | x-ray diffraction | A, B | NAG, NA | 6 (best 0.48) |
| 7APP | Structure of lipase tl from capillary grown crystal in the presence of agarose | x-ray diffraction | A, B | NAG, NA | — |
| O59952 | AlphaFold monomer V2.0 prediction for lipase (O59952) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 16 records
- PO4 · Phosphate ion · in 12 records
- CA · Calcium ion · in 8 records
- LTV · 2-hydroxy-3-(octadecanoyloxy)propyl pentacosanoate · in 8 records
- OCA · Octanoic acid (caprylic acid) · in 6 records
- MG · Magnesium ion · in 4 records
- NA · Sodium ion · in 2 records
- PLM · Palmitic acid · in 2 records
Experiment against prediction
- 1DT5 chain A against the predicted model O59952: TM-score 1.00, RMSD 0.29 Å
- 1DT5 chain A against the predicted model O59952: TM-score 1.00, RMSD 0.29 Å
- 1DU4 chain A against the predicted model O59952: TM-score 1.00, RMSD 0.30 Å
- 1DU4 chain A against the predicted model O59952: TM-score 1.00, RMSD 0.30 Å
- 1TIB chain A against the predicted model O59952: TM-score 0.99, RMSD 0.57 Å
- 1TIB chain A against the predicted model O59952: TM-score 0.99, RMSD 0.57 Å
- 1DT3 chain A against the predicted model O59952: TM-score 0.99, RMSD 0.66 Å
- 1DT3 chain A against the predicted model O59952: TM-score 0.99, RMSD 0.66 Å
- 4GHW chain A against the predicted model O59952: TM-score 0.99, RMSD 0.75 Å
- 4GHW chain A against the predicted model O59952: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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