UniProt O43598
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (O43598)
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (UniProt O43598), EC 3.2.2.-: 9 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O43598
- Protein
- 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
- EC
- 3.2.2.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 40 · 7 records with a druggable one
Structures
10 records of O43598 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P5E | Crystal structure of human DNPH1 (rcl) with 6-naphthyl-purine-riboside-monophosphate | x-ray diffraction | A, B | — | — |
| 4P5E | Crystal structure of human DNPH1 (rcl) with 6-naphthyl-purine- riboside-monophosphate | x-ray diffraction | A, B | — | — |
| 8OS9 | Structure of Homo sapiens 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1) | x-ray diffraction | A, B, C, D | — | 7 (best 0.60) |
| 8OSC | Structure of Homo sapiens 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1) bound to… | x-ray diffraction | A, B | UMP | 2 (best 0.59) |
| 8QHQ | Crystal structure of human DNPH1 bound to hmdUMP | x-ray diffraction | A, B, C, D, E, F | 5HU | 17 (best 0.72) |
| 8QHR | Crystal structure of the human DNPH1 glycosyl-enzyme intermediate | x-ray diffraction | A, B | 3DR | 2 (best 0.66) |
| 8RPS | Crystal structure of human DNPH1 mutant- D80N bound to 5hmdUMP | x-ray diffraction | C, A, B | 5HU | 5 (best 0.65) |
| 8RPT | Crystal structure of human DNPH1 mutant- D80A | x-ray diffraction | B, A | CL | 4 (best 0.55) |
| 8RQD | Crystal structure of human DNPH1 mutant-Y24F | x-ray diffraction | C, A | CL, SO4 | 3 (best 0.60) |
| O43598 | AlphaFold monomer V2.0 prediction for 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (O43598) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4P5E chain B against the predicted model O43598: TM-score 0.99, RMSD 0.43 Å
- 4P5E chain B against the predicted model O43598: TM-score 0.99, RMSD 0.43 Å
- 8QHQ chain E against the predicted model O43598: TM-score 0.99, RMSD 0.52 Å
- 8QHQ chain F against the predicted model O43598: TM-score 0.99, RMSD 0.55 Å
- 8OSC chain A against the predicted model O43598: TM-score 0.99, RMSD 0.44 Å
- 8OS9 chain D against the predicted model O43598: TM-score 0.99, RMSD 0.44 Å
- 8OS9 chain C against the predicted model O43598: TM-score 0.99, RMSD 0.47 Å
- 8OSC chain B against the predicted model O43598: TM-score 0.99, RMSD 0.63 Å
- 8QHQ chain C against the predicted model O43598: TM-score 0.98, RMSD 0.87 Å
- 8QHQ chain A against the predicted model O43598: TM-score 0.97, RMSD 0.92 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.