UniProt O43570
Carbonic anhydrase 12 (O43570)
Carbonic anhydrase 12 (UniProt O43570), EC 4.2.1.1: 55 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 156 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43570
- Protein
- Carbonic anhydrase 12
- EC
- 4.2.1.1
- Experimental structures
- 55
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 156 · 15 records with a druggable one
Structures
56 records of O43570 in the MolNFT archive: 55 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JCZ | Crystal structure of the extracellular domain of human carbonic anhydrase XII | x-ray diffraction | A, B | — | — |
| 1JCZ | Crystal structure of the extracellular domain of human carbonic anhydrase XII | x-ray diffraction | A, B | — | — |
| 1JD0 | Crystal structure of the extracellular domain of human carbonic anhydrase XII complexed with… | x-ray diffraction | A, B | — | — |
| 1JD0 | Crystal structure of the extracellular domain of human carbonic anhydrase XII complexed with… | x-ray diffraction | A, B | — | — |
| 4HT2 | Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor. | x-ray diffraction | A, B, C, D | — | — |
| 4HT2 | Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor. | x-ray diffraction | A, B, C, D | — | — |
| 4KP5 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | — | — |
| 4KP5 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | — | — |
| 4KP8 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | — | — |
| 4KP8 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | — | — |
| 4Q0L | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4Q0L | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJ0 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJ0 | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJO | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJO | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJW | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QJW | Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4WW8 | Crystal structure of human carbonic anhydrase isozyme XII with 4-Propylthiobenzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, VD9 | 7 (best 0.83) |
| 4WW8 | Crystal structure of human carbonic anhydrase isozyme XII with 4- propylthiobenzenesulfonamide | x-ray diffraction | A, B, C, D | — | — |
| 5LL5 | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, 6YH | — |
| 5LL5 | Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H… | x-ray diffraction | A, B, C, D | ZN, 6YH | — |
| 5LL9 | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, 6YQ, SO4 | — |
| 5LL9 | Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H… | x-ray diffraction | A, B, C, D | ZN, 6YQ, SO4 | — |
| 5LLO | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, 5EF | 8 (best 0.85) |
| 5LLO | Crystal structure of human carbonic anhydrase isozyme XII with 3… | x-ray diffraction | A, B, C, D | ZN, 5EF | — |
| 5LLP | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, 6Z9 | 10 (best 0.85) |
| 5LLP | Crystal structure of human carbonic anhydrase isozyme XII with 3… | x-ray diffraction | A, B, C, D | ZN, 6Z9 | — |
| 5MSA | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, 3TV | 9 (best 0.84) |
| 5MSA | Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5… | x-ray diffraction | A, B, C, D | ZN, 3TV | — |
| 5MSB | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, V13 | 9 (best 0.85) |
| 5MSB | Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5… | x-ray diffraction | A, B, C, D | ZN, V13 | — |
| 6G5L | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B, C, D | ZN, EM5 | 9 (best 0.85) |
| 6G5L | Crystal structure of human carbonic anhydrase isozyme XII with 4… | x-ray diffraction | A, B, C, D | ZN, EM5 | — |
| 6G7A | Crystal structure of human carbonic anhydrase isozyme XII 2… | x-ray diffraction | A, B, C, D | ZN, EOQ | — |
| 6QN0 | Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, J8Q | 11 (best 0.84) |
| 6QN0 | Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, J8Q | — |
| 6QNG | Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, J95 | 14 (best 0.78) |
| 6QNG | Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, J95 | — |
| 6QNL | Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, J92 | — |
| 6R6Y | Crystal structure of human carbonic anhydrase isozyme XII with 4… | x-ray diffraction | A, B, C, D | ZN, EA3 | — |
| 6R71 | Crystal structure of human carbonic anhydrase isozyme XII with… | x-ray diffraction | A, B | ZN, JTW | 5 (best 0.78) |
| 6R71 | Crystal structure of human carbonic anhydrase isozyme XII with 2… | x-ray diffraction | A, B | ZN, JTW | — |
| 6RPS | X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody… | x-ray diffraction | A, B | ZN, SO4, CD, CL | — |
| 6T5P | Human Carbonic anhydrase XII bound by 3,5-Di-tert-butylbenzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, VD8 | 11 (best 0.83) |
| 6T5P | Human carbonic anhydrase XII bound by 3,5-di-tert- butylbenzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, VD8 | — |
| 6T5Q | Human Carbonic anhydrase XII bound by 3,5-diphenylbenzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, MKQ | 10 (best 0.83) |
| 6T5Q | Human carbonic anhydrase XII bound by 3,5-diphenylbenzenesulfonamide | x-ray diffraction | A, B, C, D | ZN, MKQ | — |
| 7PP9 | Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide | x-ray diffraction | A, B, C, D | ZN, 7VZ | 15 (best 0.80) |
| 7PUU | Crystal structure of carbonic anhydrase XII with methyl 4-chloro-2… | x-ray diffraction | A, B, C, D | ZN, 84O | — |
| 7PUV | Crystal structure of carbonic anhydrase XII with methyl… | x-ray diffraction | A, B, C, D | ZN, 84Z | 10 (best 0.85) |
| 7PUV | Crystal structure of carbonic anhydrase XII with methyl 2… | x-ray diffraction | A, B, C, D | ZN, 84Z | — |
| 7PUW | Crystal structure of carbonic anhydrase XII with methyl… | x-ray diffraction | A, B, C, D | ZN, 84I | 10 (best 0.85) |
| 7PUW | Crystal structure of carbonic anhydrase XII with methyl 2-chloro-4… | x-ray diffraction | A, B, C, D | ZN, 84I | — |
| 8CO3 | Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide | x-ray diffraction | A, B, C, D | ZN, V8O | 18 (best 0.78) |
| O43570 | AlphaFold monomer V2.0 prediction for carbonic anhydrase 12 (O43570) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 36 records
- SO4 · Sulfate ion · in 3 records
- 3TV · 2,3,5,6-tetrafluoro-4-(propylsulfanyl) benzenesulfonamide · in 2 records
- 5EF · 3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl) sulfonyl]benzenesulfonamide · in 2 records
- 6YH · 4-[2-(benzimidazol-1-yl)ethanoyl]benzenesulfonamide · in 2 records
- 6YQ · 4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide · in 2 records
- 6Z9 · 3-[(1S)-1,2,3,4-tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl) sulfonyl]benzenesulfonamide · in 2 records
- 84I · methyl 2-chloranyl-4-(2-phenylethylsulfanyl)-5-sulfamoyl-benzoate · in 2 records
- 84Z · methyl 4-chloranyl-2-(phenylsulfonyl)-5-sulfamoyl-benzoate · in 2 records
- EM5 · 4-chloranyl-2-(cyclohexylamino)-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide · in 2 records
- J8Q · ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide · in 2 records
- J95 · ~{N}-butyl-4-chloranyl-2-(cyclohexylamino)-5-sulfamoyl-benzamide · in 2 records
- JTW · 4-chloranyl-~{N}-(2-hydroxyethyl)-2-(phenylsulfonyl)-5-sulfamoyl-benzamide · in 2 records
- MKQ · 3,5-diphenylbenzenesulfonamide · in 2 records
- V13 · 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl) sulfonyl]benzenesulfonamide · in 2 records
- VD8 · 3,5-di~{tert}-butylbenzenesulfonamide · in 2 records
- 7VZ · methyl 2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate · in 1 record
- 84O · Methyl 4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-benzoate · in 1 record
- CD · Cadmium ion · in 1 record
- CL · Chloride ion · in 1 record
- EA3 · 4-chloranyl-2-cyclohexylsulfanyl-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide · in 1 record
- EOQ · 4-chloranyl-~{N}-(2-hydroxyethyl)-2-[(phenylmethyl) amino]-5-sulfamoyl-benzamide · in 1 record
- J92 · methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate · in 1 record
- V8O · 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide · in 1 record
- VD9 · 4-(propylsulfanyl)benzenesulfonamide · in 1 record
Experiment against prediction
- 6QNL chain A against the predicted model O43570: TM-score 1.00, RMSD 0.21 Å
- 5LLP chain A against the predicted model O43570: TM-score 1.00, RMSD 0.21 Å
- 5LLP chain A against the predicted model O43570: TM-score 1.00, RMSD 0.21 Å
- 4QJ0 chain A against the predicted model O43570: TM-score 1.00, RMSD 0.23 Å
- 4QJ0 chain A against the predicted model O43570: TM-score 1.00, RMSD 0.23 Å
- 5LLO chain A against the predicted model O43570: TM-score 1.00, RMSD 0.24 Å
- 5LLO chain A against the predicted model O43570: TM-score 1.00, RMSD 0.24 Å
- 4WW8 chain A against the predicted model O43570: TM-score 1.00, RMSD 0.27 Å
- 4WW8 chain A against the predicted model O43570: TM-score 1.00, RMSD 0.27 Å
- 6G7A chain A against the predicted model O43570: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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