UniProt O43520
Phospholipid-transporting ATPase IC (O43520)
Phospholipid-transporting ATPase IC (UniProt O43520), EC 7.6.2.1: 17 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 192 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O43520
- Protein
- Phospholipid-transporting ATPase IC
- EC
- 7.6.2.1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 192 · 13 records with a druggable one
Structures
18 records of O43520 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7PY4 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | electron microscopy | A | NAG, MG, BEF, Y01 | 12 (best 0.78) |
| 7PY4 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | electron microscopy | A | NAG, MG, BEF, Y01 | — |
| 7VGH | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state | electron microscopy | B | NAG, MAN, MG | 18 (best 0.82) |
| 7VGH | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state | electron microscopy | B | NAG, MAN, MG | — |
| 7VGI | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2P state | electron microscopy | B | NAG, MG | 20 (best 0.78) |
| 7VGI | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2P state | electron microscopy | B | NAG, MG | — |
| 7VGJ | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state | electron microscopy | A | P5S | 18 (best 0.85) |
| 7VGJ | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2PI-ps state | electron microscopy | A | — | — |
| 8OX4 | Cryo-EM structure of ATP8B1-CDC50A in E1-ATP conformation | electron microscopy | A | NAG, ACP, MG | 11 (best 0.76) |
| 8OX5 | Cryo-EM structure of ATP8B1-CDC50A in E1P-ADP conformation | electron microscopy | A | NAG, ADP, ALF, MG | 16 (best 0.76) |
| 8OX6 | Cryo-EM structure of ATP8B1-CDC50A in E1P conformation | electron microscopy | A | NAG, MG, ALF | 9 (best 0.76) |
| 8OX7 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "closed" conformation | electron microscopy | A | NAG, MG, IP9 | 15 (best 0.76) |
| 8OX8 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "open" conformation | electron microscopy | A | NAG, MG, IP9 | 17 (best 0.77) |
| 8OX9 | Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC | electron microscopy | A | NAG, BEF, MG, POV, IP9 | 14 (best 0.78) |
| 8OXA | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PS | electron microscopy | A | NAG, VN4, MG, D39 | 12 (best 0.81) |
| 8OXB | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PC | electron microscopy | A | NAG, VN4, MG, POV | 15 (best 0.79) |
| 8OXC | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PI | electron microscopy | A | NAG, VN4, MG, PIE | 15 (best 0.77) |
| O43520 | AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase ic (O43520) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 15 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 15 records
- BEF · Beryllium trifluoride ion · in 3 records
- IP9 · (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy) phosphoryl]oxy}propane -1,2-diyl dioctanoate · in 3 records
- VN4 · oxido(dioxo)vanadium · in 3 records
- ALF · Tetrafluoroaluminate ion · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- ADP · Adenosine-5'-diphosphate · in 1 record
- D39 · (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid · in 1 record
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 1 record
- PIE · 1,2-diacyl-sn-glycero-3-phosphoinositol · in 1 record
Experiment against prediction
- 8OX6 chain A against the predicted model O43520: TM-score 0.98, RMSD 1.25 Å
- 8OX9 chain A against the predicted model O43520: TM-score 0.94, RMSD 2.80 Å
- 8OX7 chain A against the predicted model O43520: TM-score 0.94, RMSD 2.76 Å
- 7PY4 chain A against the predicted model O43520: TM-score 0.94, RMSD 2.74 Å
- 7PY4 chain A against the predicted model O43520: TM-score 0.94, RMSD 2.74 Å
- 8OX8 chain A against the predicted model O43520: TM-score 0.94, RMSD 2.82 Å
- 7VGI chain B against the predicted model O43520: TM-score 0.93, RMSD 3.31 Å
- 7VGI chain B against the predicted model O43520: TM-score 0.93, RMSD 3.31 Å
- 7VGJ chain A against the predicted model O43520: TM-score 0.92, RMSD 3.22 Å
- 7VGJ chain A against the predicted model O43520: TM-score 0.92, RMSD 3.22 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.