MolNFT v1 · #189451 · protein

Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state

7VGH: “Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state”. Electron microscopy, 3 ligands (NAG, MAN, MG). MolNFT v1 #189451 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7VGH
Type: protein
Length: 1,521 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q3MIR4, O43520
Ligands: NAG, MAN, MG

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	338	—	Q3MIR4
B	—	protein	1183	—	O43520

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains B, A
MAN · alpha-D-mannopyranose · sugar · 6 copies · chains B, A
MG · Magnesium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7VGH · Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P… · the same entry in another collection · chain A against A, TM-score 1.00
O43520 · AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase ic (O43520) · a predicted model of the same protein · chain B against A, TM-score 0.92
Q3MIR4 · AlphaFold monomer V2.0 prediction for cell cycle control protein 50B (Q3MIR4) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3MIR4
Every structure of UniProt O43520
Elsewhere: RCSB PDB 7VGH · PDBe 7VGH · UniProt Q3MIR4 · UniProt O43520

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