UniProt O43148
mRNA cap guanine-N7 methyltransferase (O43148)
mRNA cap guanine-N7 methyltransferase (UniProt O43148), EC 2.1.1.56: 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O43148
- Protein
- mRNA cap guanine-N7 methyltransferase
- EC
- 2.1.1.56
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 29 · 5 records with a druggable one
Structures
13 records of O43148 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BGV | Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH | x-ray diffraction | A, B, C, D | — | — |
| 3BGV | Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with sah | x-ray diffraction | A, B, C, D | — | — |
| 3EPP | Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin | x-ray diffraction | A, B | — | — |
| 3EPP | Crystal structure of mRNA cap guanine-N7 methyltransferase (rnmt) in complex with sinefungin | x-ray diffraction | A, B | — | — |
| 5E8J | Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM | x-ray diffraction | A, B | SAH | 9 (best 0.66) |
| 5E8J | Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with ram | x-ray diffraction | A, B | — | — |
| 5E9J | Crystal structure of the mRNA cap guanine-N7 methyltransferase - modular lobe (416-456) deletion | x-ray diffraction | A, B | SAH | 5 (best 0.69) |
| 5E9J | Crystal structure of the mRNA cap guanine-N7 methyltransferase - modular lobe (416-456) deletion | x-ray diffraction | A, B | — | — |
| 5E9W | Crystal structure of mRNA cap guanine-N7 methyltransferase obtained by limited proteolysis | x-ray diffraction | A, B, C, D | SAH | 6 (best 0.75) |
| 5E9W | Crystal structure of mRNA cap guanine-N7 methyltransferase obtained by limited proteolysis | x-ray diffraction | A, B, C, D | — | — |
| 8Q69 | Crystal structure of HsRNMT complexed with inhibitor DDD1060606 | x-ray diffraction | A, B | SAH, K7R, SO4 | 6 (best 0.68) |
| 8Q9W | Crystal structure of HsRNMT complexed with sinefungin and GMP-PnP | x-ray diffraction | A, B | SFG, SO4, GNP | 3 (best 0.74) |
| O43148 | AlphaFold monomer V2.0 prediction for mRNA cap guanine-N7 methyltransferase (O43148) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5E8J chain A against the predicted model O43148: TM-score 0.99, RMSD 0.47 Å
- 5E8J chain A against the predicted model O43148: TM-score 0.99, RMSD 0.47 Å
- 5E8J chain B against the predicted model O43148: TM-score 0.99, RMSD 0.72 Å
- 8Q69 chain B against the predicted model O43148: TM-score 0.99, RMSD 0.65 Å
- 5E9J chain B against the predicted model O43148: TM-score 0.99, RMSD 0.70 Å
- 8Q9W chain A against the predicted model O43148: TM-score 0.99, RMSD 0.76 Å
- 5E9W chain C against the predicted model O43148: TM-score 0.99, RMSD 1.01 Å
- 5E9J chain A against the predicted model O43148: TM-score 0.99, RMSD 0.85 Å
- 5E9W chain A against the predicted model O43148: TM-score 0.99, RMSD 1.02 Å
- 8Q9W chain B against the predicted model O43148: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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