UniProt O32080
Ktr system potassium uptake protein A (O32080)
Ktr system potassium uptake protein A (UniProt O32080): 44 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 185 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O32080
- Protein
- Ktr system potassium uptake protein A
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 185 · 14 records with a druggable one
Structures
45 records of O32080 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LSU | KTN Bsu222 Crystal Structure in Complex with NADH | x-ray diffraction | A, B | — | — |
| 1LSU | Ktn BSU222 crystal structure in complex with NADH | x-ray diffraction | A, B | — | — |
| 2HMS | Rectangular-shaped octameric ring structure of an RCK domain with NADH bound | x-ray diffraction | A, B, C, D | — | — |
| 2HMS | Rectangular-shaped octameric ring structure of an rck domain with NADH bound | x-ray diffraction | A, B, C, D | — | — |
| 2HMT | Diamond-shaped octameric ring structure of an RCK domain with NADH bound | x-ray diffraction | A, B | — | — |
| 2HMT | Diamond-shaped octameric ring structure of an rck domain with NADH bound | x-ray diffraction | A, B | — | — |
| 2HMU | Diamond-shaped octameric ring structure of an RCK domain with ATP bound | x-ray diffraction | A, B | — | — |
| 2HMU | Diamond-shaped octameric ring structure of an rck domain with ATP bound | x-ray diffraction | A, B | — | — |
| 2HMV | Diamond-shaped octameric ring structure of an RCK domain with ADP bound | x-ray diffraction | A, B | — | — |
| 2HMV | Diamond-shaped octameric ring structure of an rck domain with ADP bound | x-ray diffraction | A, B | — | — |
| 2HMW | Square-shaped octameric ring structure of an RCK domain with ATP bound | x-ray diffraction | A, B | — | — |
| 2HMW | Square-shaped octameric ring structure of an rck domain with ATP bound | x-ray diffraction | A, B | — | — |
| 4J7C | KtrAB potassium transporter from Bacillus subtilis | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4J7C | Ktrab potassium transporter from bacillus subtilis | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4J90 | Square-shaped octameric structure of KtrA with ATP bound | x-ray diffraction | A, B | — | — |
| 4J90 | Square-shaped octameric structure of ktra with ATP bound | x-ray diffraction | A, B | — | — |
| 4J91 | Diamond-shaped octameric structure of KtrA with ADP bound | x-ray diffraction | A, B, C, D | — | — |
| 4J91 | Diamond-shaped octameric structure of ktra with ADP bound | x-ray diffraction | A, B, C, D | — | — |
| 5BUT | Crystal structure of inactive conformation of KtrAB K+ transporter | x-ray diffraction | A, C, E, G | — | 5 (best 0.68) |
| 5BUT | Crystal structure of inactive conformation of ktrab K+ transporter | x-ray diffraction | A, C, E, G | — | — |
| 6S2J | Square conformation of KtrA R16K mutant ring with bound ATP | x-ray diffraction | A, B | ATP, MG | — |
| 6S2J | Square conformation of ktra R16K mutant ring with bound ATP | x-ray diffraction | A, B | ATP, MG | — |
| 6S5B | Non-square conformation of KtrA R16K mutant ring with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H | ADP | 20 (best 0.71) |
| 6S5B | Non-square conformation of ktra R16K mutant ring with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H | ADP | — |
| 6S5C | Square conformation of KtrA WT ring with bound ATP and calcium | x-ray diffraction | A, B | ATP, CA | 9 (best 0.51) |
| 6S5C | Square conformation of ktra wt ring with bound ATP and calcium | x-ray diffraction | A, B | ATP, CA | — |
| 6S5D | Square conformation of KtrA R16A mutant ring with bound ATP | x-ray diffraction | A, B | ATP, MG | 7 (best 0.58) |
| 6S5D | Square conformation of ktra R16A mutant ring with bound ATP | x-ray diffraction | A, B | ATP, MG | — |
| 6S5E | Non-square conformation of KtrA A80P mutant ring with bound ATP | x-ray diffraction | A, B, C, D, E, F, G, H | ATP | 20 (best 0.71) |
| 6S5E | Non-square conformation of ktra A80P mutant ring with bound ATP | x-ray diffraction | A, B, C, D, E, F, G, H | ATP | — |
| 6S5G | Non-square conformation of ktra A80P mutant ring with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H | ADP | — |
| 6S5N | Non-square conformations of KtrA E125Q mutant rings with bound ATP | x-ray diffraction | A, B, C, D, E, F, G, H | ATP | 20 (best 0.66) |
| 6S5N | Non-square conformations of ktra E125Q mutant rings with bound ATP | x-ray diffraction | A, B, C, D, E, F, G, H | ATP | — |
| 6S5O | Non-square conformations of KtrA E125Q mutant rings with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H | ADP | 20 (best 0.58) |
| 6S5O | Non-square conformations of ktra E125Q mutant rings with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H | ADP | — |
| 6S7R | Non-square conformations of KtrA R16A mutant rings with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | ADP | 20 (best 0.72) |
| 6S7R | Non-square conformations of ktra R16A mutant rings with bound ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | ADP | — |
| 8K16 | KtrA bound with ATP and thallium | x-ray diffraction | A, B | ATP, TL | 7 (best 0.58) |
| 8K1K | KtrA bound with ATP and sodium | x-ray diffraction | A, B | ATP, NA | 7 (best 0.65) |
| 8K1S | Potassium transporter KtrAB from Bacillus subtilis in ADP-bound state | electron microscopy | A, B, C, D, E, F, G, H | ADP | 6 (best 0.50) |
| 8K1T | Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of MgCl2 | electron microscopy | A, B, C, D, E, F, G, H | ATP, NA | 14 (best 0.78) |
| 8POO | Low resolution structure of inactive conformation of the Ktr cation channel in presence of ATP and… | x-ray diffraction | C, D, E, G | — | 3 (best 0.67) |
| 8XMH | Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and… | electron microscopy | A, B, C, D, E, F, G, H | ATP, NA | 14 (best 0.76) |
| 8XMI | Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and… | electron microscopy | A, B, C, D, E, F, G, H | ATP, NA | 13 (best 0.77) |
| O32080 | AlphaFold monomer V2.0 prediction for ktr system potassium uptake protein a (O32080) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6S5D chain A against the predicted model O32080: TM-score 0.99, RMSD 0.44 Å
- 6S5D chain A against the predicted model O32080: TM-score 0.99, RMSD 0.44 Å
- 6S7R chain G against the predicted model O32080: TM-score 0.99, RMSD 0.45 Å
- 6S7R chain P against the predicted model O32080: TM-score 0.99, RMSD 0.36 Å
- 6S2J chain A against the predicted model O32080: TM-score 0.99, RMSD 0.45 Å
- 6S2J chain A against the predicted model O32080: TM-score 0.99, RMSD 0.45 Å
- 6S5B chain B against the predicted model O32080: TM-score 0.99, RMSD 0.45 Å
- 6S5B chain F against the predicted model O32080: TM-score 0.99, RMSD 0.46 Å
- 6S5D chain B against the predicted model O32080: TM-score 0.99, RMSD 0.47 Å
- 6S5D chain B against the predicted model O32080: TM-score 0.99, RMSD 0.47 Å
Elsewhere
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