UniProt O30298
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (O30298)
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (UniProt O30298), EC 3.1.3.11, 3.1.3.25: 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 17 pockets. Binding sites, druggability and…
- UniProt
- O30298
- Protein
- Fructose-1,6-bisphosphatase/inositol-1-monophosphatase
- EC
- 3.1.3.11, 3.1.3.25
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 17 · 4 records with a druggable one
Structures
24 records of O30298 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LBV | Crystal Structure of apo-form (P21) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBV | Crystal structure of apo-form (P21) of dual activity FBPASE/IMPASE (AF2372) from archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBW | Crystal Structure of apo-form (P32) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBW | Crystal structure of apo-form (P32) of dual activity FBPASE/IMPASE (AF2372) from archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBX | Crystal Structure of a ternary complex of dual activity FBPase/IMPase (AF2372) from Archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBX | Crystal structure of a ternary complex of dual activity FBPASE/IMPASE (AF2372) from archaeoglobus… | x-ray diffraction | A, B | — | — |
| 1LBY | Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from… | x-ray diffraction | A, B | — | — |
| 1LBY | Crystal structure of a complex (P32 crystal form) of dual activity FBPASE/IMPASE (AF2372) from… | x-ray diffraction | A, B | — | — |
| 1LBZ | Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from… | x-ray diffraction | A, B | — | — |
| 1LBZ | Crystal structure of a complex (P32 crystal form) of dual activity FBPASE/IMPASE (AF2372) from… | x-ray diffraction | A, B | — | — |
| 6B5Z | Impase (AF2372) with 25 mm asp | x-ray diffraction | A, B | SO4, MG, INS | — |
| 6B60 | IMPase (AF2372) with 25 mM Glutamate | x-ray diffraction | A, B | GLU, SO4, MG | 4 (best 0.69) |
| 6B60 | Impase (AF2372) with 25 mm glutamate | x-ray diffraction | A, B | SO4, MG | — |
| 6B61 | IMPase (AF2372) with 25 mM Asp | x-ray diffraction | A, B | PO4, MG, ASP | 4 (best 0.68) |
| 6B61 | Impase (AF2372) with 25 mm asp | x-ray diffraction | A, B | PO4, MG | — |
| 6B62 | Impase (AF2372) with 400 mm glutamate | x-ray diffraction | A, B | MG, SO4 | — |
| 6B63 | IMPase (AF2372) with 25 mM Asp | x-ray diffraction | A, B | CU7, PO4, MG, SO4 | 4 (best 0.69) |
| 6B63 | Impase (AF2372) with 25 mm asp | x-ray diffraction | A, B | CU7, PO4, MG, SO4 | — |
| 6B64 | IMPase (AF2372) with 25 mM Asp | x-ray diffraction | A, B | ASP, SO4, MG | 5 (best 0.69) |
| 6B64 | Impase (AF2372) with 25 mm asp | x-ray diffraction | A, B | SO4, MG | — |
| 6B65 | Impase (AF2372) R92Q/K164E | x-ray diffraction | A, B | SO4, MG | — |
| 6B66 | IMPase (AF2372) R92Q/K164E with 400 mM Glutamate | x-ray diffraction | A, B | MG, SO4 | — |
| 6B66 | Impase (AF2372) R92Q/K164E with 400 mm glutamate | x-ray diffraction | A, B | MG, SO4 | — |
| O30298 | AlphaFold monomer V2.0 prediction for fructose-1,6-BISPHOSPHATASE/INOSITOL-1-monophosphatase… | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 13 records
- SO4 · Sulfate ion · in 11 records
- PO4 · Phosphate ion · in 4 records
- ASP · Aspartic acid · in 2 records
- CU7 · (2R)-2,3-dihydroxypropyl (2S)-2,3-dihydroxypropyl hydrogen phosphate · in 2 records
- GLU · Glutamic acid · in 1 record
- INS · 1,2,3,4,5,6-hexahydroxy-cyclohexane · in 1 record
Experiment against prediction
- 6B64 chain B against the predicted model O30298: TM-score 1.00, RMSD 0.20 Å
- 6B64 chain B against the predicted model O30298: TM-score 0.98, RMSD 0.20 Å
- 6B64 chain A against the predicted model O30298: TM-score 1.00, RMSD 0.21 Å
- 6B64 chain A against the predicted model O30298: TM-score 0.98, RMSD 0.21 Å
- 6B5Z chain B against the predicted model O30298: TM-score 0.99, RMSD 0.23 Å
- 6B5Z chain A against the predicted model O30298: TM-score 0.99, RMSD 0.24 Å
- 6B62 chain B against the predicted model O30298: TM-score 0.98, RMSD 0.24 Å
- 6B62 chain A against the predicted model O30298: TM-score 0.98, RMSD 0.24 Å
- 6B61 chain A against the predicted model O30298: TM-score 1.00, RMSD 0.25 Å
- 6B61 chain A against the predicted model O30298: TM-score 0.98, RMSD 0.25 Å
Elsewhere
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