UniProt O15296
Polyunsaturated fatty acid lipoxygenase ALOX15B (O15296)
Polyunsaturated fatty acid lipoxygenase ALOX15B (UniProt O15296), EC 1.13.11.-, 1.13.11.33: 5 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 19 pockets. Binding sites, druggability and experiment…
- UniProt
- O15296
- Protein
- Polyunsaturated fatty acid lipoxygenase ALOX15B
- EC
- 1.13.11.-, 1.13.11.33
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 19 · 2 records with a druggable one
Structures
6 records of O15296 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NRE | The structure of human 15-lipoxygenase-2 with a substrate mimic | x-ray diffraction | A | — | — |
| 4NRE | The structure of human 15-lipoxygenase-2 with a substrate mimic | x-ray diffraction | A | — | — |
| 7LAF | 15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor | x-ray diffraction | A, B | MN, XRP | 13 (best 0.86) |
| 7LAF | 15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor | x-ray diffraction | A, B | MN, XRP | — |
| 8VIY | 15-Lipoxygenase-2 V427L | x-ray diffraction | A | FE2, SO4, CA | 6 (best 0.78) |
| O15296 | AlphaFold monomer V2.0 prediction for polyunsaturated fatty acid lipoxygenase ALOX15B (O15296) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4NRE chain A against the predicted model O15296: TM-score 0.99, RMSD 0.77 Å
- 4NRE chain A against the predicted model O15296: TM-score 0.99, RMSD 0.77 Å
- 8VIY chain A against the predicted model O15296: TM-score 0.99, RMSD 0.78 Å
- 7LAF chain B against the predicted model O15296: TM-score 0.99, RMSD 0.69 Å
- 7LAF chain B against the predicted model O15296: TM-score 0.99, RMSD 0.69 Å
- 7LAF chain A against the predicted model O15296: TM-score 0.99, RMSD 0.76 Å
- 7LAF chain A against the predicted model O15296: TM-score 0.99, RMSD 0.76 Å
Elsewhere
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