MolNFT v1 · #180762 · protein
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
7LAF: “15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor”. X-ray diffraction, 2 ligands (XRP, MN). MolNFT v1 #180762 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LAF
- Type
- protein
- Length
- 1,318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O15296
- Ligands
- XRP, MN
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 663 | — | O15296 |
| B | — | protein | 655 | — | O15296 |
Ligands and binding sites
- XRP · 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LAF · 15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- O15296 · AlphaFold monomer V2.0 prediction for polyunsaturated fatty acid lipoxygenase ALOX15B… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15296
- Elsewhere: RCSB PDB 7LAF · PDBe 7LAF · UniProt O15296
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