UniProt O15075
Serine/threonine-protein kinase DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (UniProt O15075), EC 2.7.11.1: 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O15075
- Protein
- Serine/threonine-protein kinase DCLK1
- EC
- 2.7.11.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 5 · 1 record with a druggable one
Structures
17 records of O15075 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MFW | Structure of N-terminal doublecortin domain from dclk: selenomethionine labeled protein | x-ray diffraction | A | — | — |
| 1MFW | Structure of N-terminal doublecortin domain from dclk: selenomethionine labeled protein | x-ray diffraction | A | — | — |
| 1MG4 | Structure of N-terminal doublecortin domain from dclk: wild type protein | x-ray diffraction | A | — | — |
| 1MG4 | Structure of N-terminal doublecortin domain from dclk: wild type protein | x-ray diffraction | A | — | — |
| 1UF0 | Solution structure of the N-terminal DCX domain of human doublecortin-like kinase | solution nmr | A | — | — |
| 1UF0 | Solution structure of the N-terminal dcx domain of human doublecortin- like kinase | solution nmr | A | — | — |
| 5JZJ | Crystal structure of DCLK1-KD in complex with AMPPN | x-ray diffraction | A, B | MG, SO4, AN2 | — |
| 5JZJ | Crystal structure of DCLK1-kd in complex with amppn | x-ray diffraction | A, B | — | — |
| 5JZN | Crystal structure of DCLK1-kd in complex with nvp-TAE684 | x-ray diffraction | A, B | — | — |
| 6KYQ | Crystal structure of DCLK1 Autoinhibited Kinase Domain | x-ray diffraction | A, B | — | 5 (best 0.77) |
| 6KYQ | Crystal structure of DCLK1 autoinhibited kinase domain | x-ray diffraction | A, B | — | — |
| 6KYR | Crystal structure of DCLK1 mutant (P675L) autoinhibited kinase domain | x-ray diffraction | A, B | — | — |
| 7F3G | Crystal structure of DCLK1 kinase domain in complex with ruxolitinib | x-ray diffraction | A, B | RXT | — |
| 7KX6 | Crystal structure of DCLK1-kd in complex with XMD8-85 | x-ray diffraction | A, B | X7Y | — |
| 7KX8 | Crystal structure of DCLK1-cter in complex with fmf-03-055-1 | x-ray diffraction | A, B | X8J | — |
| 7KXW | Crystal structure of DCLK1-kd in complex with DCLK1-in-1 | x-ray diffraction | A, B | XBD | — |
| O15075 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase DCLK1 (O15075) | predicted | A | — | — |
Ligands
- AN2 · Amp phosphoramidate · in 1 record
- MG · Magnesium ion · in 1 record
- RXT · (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile · in 1 record
- SO4 · Sulfate ion · in 1 record
- X7Y · 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-B][1, 4]benzodiazepin-6-one · in 1 record
- X8J · 5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl) phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · in 1 record
- XBD · 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · in 1 record
Experiment against prediction
- 6KYQ chain B against the predicted model O15075: TM-score 0.99, RMSD 0.48 Å
- 6KYQ chain B against the predicted model O15075: TM-score 0.99, RMSD 0.48 Å
- 6KYR chain B against the predicted model O15075: TM-score 0.99, RMSD 0.59 Å
- 6KYQ chain A against the predicted model O15075: TM-score 0.99, RMSD 0.62 Å
- 6KYQ chain A against the predicted model O15075: TM-score 0.99, RMSD 0.62 Å
- 6KYR chain A against the predicted model O15075: TM-score 0.99, RMSD 0.66 Å
- 7KXW chain A against the predicted model O15075: TM-score 0.97, RMSD 1.36 Å
- 7KX8 chain A against the predicted model O15075: TM-score 0.95, RMSD 1.60 Å
- 7KXW chain B against the predicted model O15075: TM-score 0.94, RMSD 1.73 Å
- 7KX6 chain A against the predicted model O15075: TM-score 0.94, RMSD 1.85 Å
Elsewhere
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