MolNFT v1 · #178062 · protein
Crystal structure of DCLK1 kinase domain in complex with ruxolitinib
7F3G: “Crystal structure of DCLK1 kinase domain in complex with ruxolitinib”. X-ray diffraction, 1 ligand (RXT). MolNFT v1 #178062 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7F3G
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O15075
- Ligands
- RXT
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 273 | — | O15075 |
| B | — | protein | 266 | — | O15075 |
Ligands and binding sites
- RXT · (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7F3G · Crystal structure of DCLK1 kinase domain in complex with ruxolitinib · the same entry in another collection · chain A against A, TM-score 1.00
- O15075 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase DCLK1 (O15075) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15075
- Elsewhere: RCSB PDB 7F3G · PDBe 7F3G · UniProt O15075
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