UniProt O14842
Free fatty acid receptor 1 (O14842)
Free fatty acid receptor 1 (UniProt O14842), EC 3.2.1.17: 13 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O14842
- Protein
- Free fatty acid receptor 1
- EC
- 3.2.1.17
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 46 · 8 records with a druggable one
Structures
14 records of O14842 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PHU | Crystal structure of Human GPR40 bound to allosteric agonist TAK-875 | x-ray diffraction | A | — | — |
| 4PHU | Crystal structure of human GPR40 bound to allosteric agonist tak-875 | x-ray diffraction | A | — | — |
| 5KW2 | The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and… | x-ray diffraction | A | 6XQ | 4 (best 0.56) |
| 5KW2 | The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and… | x-ray diffraction | A | 6XQ | — |
| 5TZR | GPR40 in complex with partial agonist MK-8666 | x-ray diffraction | A | NA, MK6 | 4 (best 0.70) |
| 5TZR | GPR40 in complex with partial agonist mk-8666 | x-ray diffraction | A | NA, MK6 | — |
| 5TZY | GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666 | x-ray diffraction | A | MK6, 7OS | 7 (best 0.71) |
| 5TZY | GPR40 in complex with agopam AP8 and partial agonist mk-8666 | x-ray diffraction | A | MK6, 7OS | — |
| 8EIT | Structure of FFAR1-Gq complex bound to DHA | electron microscopy | R | HXA | 8 (best 0.74) |
| 8EJC | Structure of FFAR1-Gq complex bound to TAK-875 | electron microscopy | R | 2YB | 6 (best 0.73) |
| 8EJK | Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | electron microscopy | R | 2YB | 7 (best 0.75) |
| 8T3V | Cryo-EM structure of the DHA bound FFA1-Gq complex | electron microscopy | R | CLR, HXA | 5 (best 0.72) |
| 9K1C | Cryo-EM structure of the DHA bound FFA1-Gi complex | electron microscopy | R | HXA | 5 (best 0.77) |
| O14842 | AlphaFold monomer V2.0 prediction for free fatty acid receptor 1 (O14842) | predicted | A | — | — |
Ligands
- MK6 · (5ar,6s,6as)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl) propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5A,6,6A-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid · in 4 records
- HXA · Docosa-4,7,10,13,16,19-hexaenoic acid · in 3 records
- 2YB · [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid · in 2 records
- 6XQ · (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid · in 2 records
- 7OS · (2S,3R)-3-cyclopropyl-3-[(2R)-2-(1-{(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl}piperidin-4-yl)-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid · in 2 records
- NA · Sodium ion · in 2 records
- CLR · Cholesterol · in 1 record
Experiment against prediction
- 8T3V chain R against the predicted model O14842: TM-score 0.96, RMSD 1.36 Å
- 8EJC chain R against the predicted model O14842: TM-score 0.95, RMSD 1.43 Å
- 8EJK chain R against the predicted model O14842: TM-score 0.95, RMSD 1.46 Å
- 8EIT chain R against the predicted model O14842: TM-score 0.95, RMSD 1.48 Å
- 9K1C chain R against the predicted model O14842: TM-score 0.92, RMSD 1.90 Å
- 5TZR chain A against the predicted model O14842: TM-score 0.62, RMSD 0.97 Å
- 5TZR chain A against the predicted model O14842: TM-score 0.62, RMSD 0.97 Å
- 5TZY chain A against the predicted model O14842: TM-score 0.64, RMSD 1.22 Å
- 5TZY chain A against the predicted model O14842: TM-score 0.64, RMSD 1.22 Å
- 4PHU chain A against the predicted model O14842: TM-score 0.62, RMSD 0.98 Å
Elsewhere
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