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Ligand · MK6

MK6 · (5ar,6s,6as)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl) propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5A,6,6A-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

MK6, (5ar,6s,6as)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl) propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5A,6,6A-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid (C29 H31 N O6 S, 521.6 g/mol), in the MolNFT structures on…

Component
MK6
Formula
C29 H31 N O6 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

MK6 in 2 structures; the first of them:

  • 5TZR · GPR40 in complex with partial agonist mk-8666 · MK6 A2402 · binds PRO80, ALA83, VAL84, PHE87, TYR91, LEU135, LEU138, GLY139 and 8 more
  • 5TZY · GPR40 in complex with agopam AP8 and partial agonist mk-8666 · MK6 A2402 · binds PRO80, ALA83, VAL84, PHE87, TYR91, LEU135, LEU138, GLY139 and 9 more

Residues it binds most

LEU 2, ARG 2, PHE 2, TYR 2, GLY 2, VAL 2, ALA 2, PRO 2, ASN 1, TRP 1 (residue and the binding sites it lines).

Found with

  • OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
  • 7OS · (2S,3R)-3-cyclopropyl-3-[(2R)-2-(1-{(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl}piperidin-4-yl)-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid
  • NA · Sodium ion
  • 1PE · Pentaethylene glycol
  • MLI · Malonate ion

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