UniProt O13828
mRNA decapping complex subunit 2 (O13828)
mRNA decapping complex subunit 2 (UniProt O13828), EC 3.-.-.-, 3.6.1.62: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O13828
- Protein
- mRNA decapping complex subunit 2
- EC
- 3.-.-.-, 3.6.1.62
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 2 records with a druggable one
Structures
19 records of O13828 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2A6T | Crystal structure of S.pombe mRNA decapping enzyme Dcp2p | x-ray diffraction | A, B | — | — |
| 2A6T | Crystal structure of S.POMBE mRNA decapping enzyme DCP2P | x-ray diffraction | A, B | — | — |
| 2QKL | The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex | x-ray diffraction | B | — | — |
| 2QKL | The crystal structure of fission yeast mRNA decapping enzyme DCP1-DCP2 complex | x-ray diffraction | B | — | — |
| 2QKM | The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex | x-ray diffraction | B, D, F, H | — | — |
| 2QKM | The crystal structure of fission yeast mRNA decapping enzyme DCP1-DCP2 complex | x-ray diffraction | B, D, F, H | — | — |
| 4A54 | Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6 | solution nmr | B | — | — |
| 4A54 | Structural basis of the DCP1:DCP2 mRNA decapping complex activation by EDC3 and SCD6 | solution nmr | B | — | — |
| 5J3T | Crystal structure of S. pombe Dcp2:Dcp1:Edc1 mRNA decapping complex | x-ray diffraction | B | MG | 4 (best 0.54) |
| 5J3T | Crystal structure of S. pombe DCP2:DCP1:EDC1 mRNA decapping complex | x-ray diffraction | B | — | — |
| 5J3Y | Crystal structure of S. pombe Dcp2:Dcp1 mRNA decapping complex | x-ray diffraction | B, D | — | — |
| 5J3Y | Crystal structure of S. pombe DCP2:DCP1 mRNA decapping complex | x-ray diffraction | B, D | — | — |
| 5KQ1 | Crystal structure of S. pombe Dcp1/Dcp2 in complex with H. sapiens PNRC2 | x-ray diffraction | B, E | — | — |
| 5KQ1 | Crystal structure of S. pombe DCP1/DCP2 in complex with H. sapiens PNRC2 | x-ray diffraction | B, E | — | — |
| 5KQ4 | Crystal structure of S. pombe Dcp1/Dcp2 in complex with H. sapiens PNRC2 and synthetic cap analog | x-ray diffraction | E, B | 6VQ | 8 (best 0.70) |
| 5KQ4 | Crystal structure of S. pombe DCP1/DCP2 in complex with H. sapiens PNRC2 and synthetic cap analog | x-ray diffraction | E, B | 6VQ | — |
| 5N2V | Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme | x-ray diffraction | B, E | MG, M7G | — |
| 5N2V | Changes in conformational equilibria regulate the activity of the DCP2 decapping enzyme | x-ray diffraction | B, E | MG, 8NK | — |
| O13828 | AlphaFold monomer V2.0 prediction for mRNA decapping complex subunit 2 (O13828) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 3 records
- 6VQ · [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl] [[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-oxidanyl-phosphoryl] hydrogen phosphate · in 2 records
- 8NK · 7-methylguanosine 5'-diphosphate · in 1 record
- M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · in 1 record
Experiment against prediction
- 5N2V chain B against the predicted model O13828: TM-score 0.96, RMSD 1.12 Å
- 5N2V chain B against the predicted model O13828: TM-score 0.96, RMSD 1.12 Å
- 5N2V chain E against the predicted model O13828: TM-score 0.96, RMSD 1.15 Å
- 5N2V chain E against the predicted model O13828: TM-score 0.96, RMSD 1.15 Å
- 2QKL chain B against the predicted model O13828: TM-score 0.85, RMSD 1.69 Å
- 2QKL chain B against the predicted model O13828: TM-score 0.85, RMSD 1.69 Å
- 2A6T chain B against the predicted model O13828: TM-score 0.74, RMSD 1.85 Å
- 2A6T chain B against the predicted model O13828: TM-score 0.74, RMSD 1.85 Å
- 2QKM chain B against the predicted model O13828: TM-score 0.62, RMSD 1.83 Å
- 2QKM chain B against the predicted model O13828: TM-score 0.62, RMSD 1.83 Å
Elsewhere
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