UniProt O00555
Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide (O00555)
Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide (UniProt O00555): 5 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 54 pockets. Binding sites, druggability and experiment against…
- UniProt
- O00555
- Protein
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 54 · 5 records with a druggable one
Structures
6 records of O00555 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BXK | Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex | x-ray diffraction | B, D | — | 4 (best 0.57) |
| 3BXK | Crystal structure of the P/Q-type calcium channel (CAV2.1) iq domain and CA2+CALMODULIN complex | x-ray diffraction | B, D | — | 4 (best 0.57) |
| 8X90 | P/Q type calcium channel | electron microscopy | A | PS1, CLR, PT5, CA, NAG, Y01 | 16 (best 0.85) |
| 8X91 | P/Q type calcium channel in complex with omega-conotoxin MVIIC | electron microscopy | A | CA, CLR, PT5, NAG, Y01, 3PE | 15 (best 0.84) |
| 8X93 | P/Q type calcium channel in complex with omega-Agatoxin IVA | electron microscopy | A | CA, CLR, PT5, NAG, Y01, 3PE | 15 (best 0.84) |
| O00555 | AlphaFold monomer V2.0 prediction for voltage-dependent P/Q-type calcium channel subunit alpha-1A… | predicted | A | — | — |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 3 records
- CA · Calcium ion · in 3 records
- CLR · Cholesterol · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- PS1 · 1,2-didecanoyl-sn-glycero-3-[phospho-L-serine] · in 1 record
Experiment against prediction
- 8X90 chain A against the predicted model O00555: TM-score 0.94, RMSD 2.75 Å
- 8X91 chain A against the predicted model O00555: TM-score 0.94, RMSD 2.81 Å
- 8X93 chain A against the predicted model O00555: TM-score 0.94, RMSD 2.77 Å
- 3BXK chain D against the predicted model O00555: TM-score 0.76, RMSD 0.44 Å
- 3BXK chain D against the predicted model O00555: TM-score 0.76, RMSD 0.44 Å
- 3BXK chain B against the predicted model O00555: TM-score 0.70, RMSD 0.34 Å
- 3BXK chain B against the predicted model O00555: TM-score 0.70, RMSD 0.34 Å
Elsewhere
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