UniProt L0E155
Flavin-dependent halogenase (L0E155)
Flavin-dependent halogenase (UniProt L0E155): 15 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- L0E155
- Protein
- Flavin-dependent halogenase
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 50 · 7 records with a druggable one
Structures
16 records of L0E155 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WGR | Crystal Structure of Wild-type MalA', premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | 6 (best 0.80) |
| 5WGR | Crystal structure of wild-type mala', premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | — |
| 5WGS | Crystal Structure of MalA' H253F, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | 8 (best 0.80) |
| 5WGS | Crystal structure of mala' H253F, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | — |
| 5WGT | Crystal Structure of MalA' H253A, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | 7 (best 0.79) |
| 5WGT | Crystal structure of mala' H253A, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | — |
| 5WGU | Crystal Structure of MalA' E494D, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | 8 (best 0.79) |
| 5WGU | Crystal structure of mala' E494D, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | — |
| 5WGV | Crystal structure of mala' C112S/C128S, premalbrancheamide complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, PM7 | — |
| 5WGW | Crystal Structure of Wild-type MalA', malbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, MB5 | 6 (best 0.79) |
| 5WGW | Crystal structure of wild-type mala', malbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, MB5 | 6 (best 0.79) |
| 5WGX | Crystal Structure of MalA' H253A, malbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, MB5 | 9 (best 0.79) |
| 5WGX | Crystal structure of mala' H253A, malbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, MB5 | — |
| 5WGY | Crystal structure of mala' C112S/C128S, malbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, MB5 | — |
| 5WGZ | Crystal structure of wild-type mala', isomalbrancheamide B complex | x-ray diffraction | A | FAD, CD, ZN, SO4, CL, IM7 | — |
| L0E155 | AlphaFold monomer V2.0 prediction for flavin-dependent halogenase mala (L0E155) | predicted | A | — | — |
Ligands
- CD · Cadmium ion · in 15 records
- CL · Chloride ion · in 15 records
- FAD · Flavin-adenine dinucleotide · in 15 records
- SO4 · Sulfate ion · in 15 records
- ZN · Zinc ion · in 15 records
- PM7 · (5as,12as,13as)-12,12-dimethyl-2,3,11,12,12A,13-hexahydro-1H,5H,6H-5A,13A-(epiminomethano) indolizino[7,6-b]carbazol-14-one · in 9 records
- MB5 · (5as,12as,13as)-9-chloro-12,12-dimethyl-2,3,11,12,12A, 13-hexahydro-1H,5H,6H-5A,13A-(epiminomethano) indolizino[7,6-b]carbazol-14-one · in 5 records
- IM7 · (5as,12as,13as)-8-chloro-12,12-dimethyl-2,3,11,12,12A, 13-hexahydro-1H,5H,6H-5A,13A-(epiminomethano) indolizino[7,6-b]carbazol-14-one · in 1 record
Experiment against prediction
- 5WGW chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.27 Å
- 5WGW chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.27 Å
- 5WGX chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.34 Å
- 5WGX chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.34 Å
- 5WGR chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.35 Å
- 5WGR chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.35 Å
- 5WGY chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.38 Å
- 5WGT chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.40 Å
- 5WGT chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.40 Å
- 5WGV chain A against the predicted model L0E155: TM-score 1.00, RMSD 0.41 Å
Elsewhere
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