UniProt J9VSJ6
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (J9VSJ6)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (UniProt J9VSJ6): 8 experimental structures on GenesisL1, 11 ligands bound, 66 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- J9VSJ6
- Protein
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 66 · 8 records with a druggable one
Structures
8 records of J9VSJ6 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7T08 | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q | x-ray diffraction | A | 3FX, XO1, FPP | 8 (best 0.78) |
| 7T09 | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d | x-ray diffraction | A | 3FX, XMV, FPP | 8 (best 0.78) |
| 7T0A | Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f | x-ray diffraction | A | 3FX, XMY | 8 (best 0.76) |
| 7T0B | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g | x-ray diffraction | A | 3FX, XO4, FPP | 8 (best 0.79) |
| 7T0C | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e | x-ray diffraction | A | XN4, 3FX, FPP | 9 (best 0.78) |
| 7T0D | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k | x-ray diffraction | A | SO4, 3FX, XO7, FPP | 10 (best 0.83) |
| 7T0E | Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b | x-ray diffraction | A | 3FX, FPP, XOA | 8 (best 0.80) |
| 8T70 | Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide | x-ray diffraction | A | 3FX, FII | 7 (best 0.77) |
Ligands
- 3FX · (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid · in 8 records
- FPP · Farnesyl diphosphate · in 6 records
- FII · [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
- XMV · 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile · in 1 record
- XMY · (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
- XN4 · (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
- XO1 · 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile · in 1 record
- XO4 · (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
- XO7 · (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
- XOA · (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one · in 1 record
Elsewhere
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